Results 41 to 50 of about 13,566,757 (346)

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Nrf2 signaling and cell survival [PDF]

Toxicology and Applied Pharmacology, 2010
Nrf2:INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to link Nrf2 to the ubiquitin ligase Cul3-Rbx1 complex that ubiquitinate and degrade Nrf2. Under basal conditions, cytosolic INrf2/Cul3-Rbx1 is constantly degrading Nrf2.
Suryakant K. Niture, Anil K. Jaiswal, Jun Shen, James W. Kaspar   +3 more
openaire   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Nature Communications, 2019
Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting ...
Søs Grønbæk Holdgaard, Valentina Cianfanelli, Emanuela Pupo, Matteo Lambrughi, Michal Lubas, Julie C. Nielsen, Susana Eibes, Emiliano Maiani, Lea M. Harder, Nicole Wesch, Mads Møller Foged, Kenji Maeda, Francesca Nazio, Laura R. de la Ballina, Volker Dötsch, Andreas Brech, Lisa B. Frankel, Marja Jäättelä, Franco Locatelli, Marin Barisic, Jens S. Andersen, Simon Bekker-Jensen, Anders H. Lund, Vladimir V. Rogov, Elena Papaleo, Letizia Lanzetti, Daniela De Zio, Francesco Cecconi   +27 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Retinal degenerative diseases: role of dietary supplements in retinal health

Discover Food
Retinal degeneration is a progressive condition that affects the retina, the light-sensitive layer, and deteriorates the inner retinal cells that encompass retinal pigment epithelium, photoreceptors, and ganglion cells that are essential for eyesight ...
D. Mohan Kumar, Priti Talwar
doaj   +1 more source

Cell Defence and Survival [PDF]

, 2009
Central to immune defence mechanisms is the role of transcription factor nuclear factor kappa B (NF-kB). This is a complex biochemical topic with ever more controls revealed. NF-kB determines the production of proinflammatory cytokines and chemokines. Pharmacologists step in with possible means of control.
openaire   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

SNP Analysis of the SOD1 gene involved in Amyotrophic Lateral Sclerosis (ALS)

Journal of Taibah University for Science
ALS is a rare neurodegenerative disease causing the loss of motor neurons in the brain and spinal cord. Mutations in over forty genes, particularly the Superoxide Dismutase 1 (SOD1) gene, are linked to ALS.
Hetal Patel, Anandita Banerjee, Pritha Saha, Subramaniyan Divya, Palaniyandi Ravanan, Priti Talwar   +5 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source