Results 91 to 100 of about 593,168 (347)
Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity
Advanced Science, EarlyView.Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang +25 more
wiley +1 more source
. Modern concepts on carcinogenesis: the value of insufficiency of malignant cell elimination mechanisms in the tumor progression in case of neoplasia at different localizations [PDF]
Саратовский научно-медицинский журнал, 2016 The article presents the review of contemporary concepts of tumor induction mechanisms applicable for neoplastic transformation, promotion and proliferation.
Chesnokova N.P. +4 more
doaj
Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. [PDF]
, 2015 The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental
Bosco MC +10 more
core +1 more source
Pleiotropic Role of HSF1 in Neoplastic Transformation
Current Cancer Drug Targets, 2014 HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions.
Natalia Vydra +2 more
semanticscholar +1 more source
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, EarlyView.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
Nature Communications, 2016 It is unclear whether there is a progenitor/stem cell in the basal layer of the urothelium in the bladder. Here, the authors identify Keratin14 positive cells that can regenerate the bladder in both a natural and injury-induced manner, and following ...
George Papafotiou +5 more
doaj +1 more source
, 2010 Aggregation of animal cells in culture comprises a series of motility, collision and adhesion processes of basic relevance for tissue engineering, bioseparations, oncology research and \textit{in vitro} drug testing.
Alves, S. G., Martins, M. L.
core +1 more source
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells [PDF]
, 2015 The final published version can be found here: http://dx.doi.org/10.1073/pnas ...
Anna Karlsson +18 more
core +1 more source
Advanced Science, EarlyView.TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han +10 more
wiley +1 more source
iScience, 2020 Summary: Glioblastoma (GBM) may arise from astrocytes through a multistep process involving a progressive accumulation of mutations. We explored whether GBM-derived extracellular vesicles (EVs) may facilitate neoplastic transformation and malignant ...
Ailiang Zeng +13 more
doaj +1 more source