Alternative Splicing and Its Impact as a Cancer Diagnostic Marker [PDF]
Genomics & Informatics, 2012 Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions.
Yun-Ji Kim, Heui-Soo Kim
doaj +1 more source
Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation. [PDF]
PLoS ONE, 2015 Comprehensive analysis of alterations in gene expression along with neoplastic transformation in human cells provides valuable information about the molecular mechanisms underlying transformation.
Masao Takeuchi +13 more
doaj +1 more source
The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation [PDF]
, 2022 The decisive role of Embryology in understanding the evolution of animal forms is founded and deeply rooted in the history of science. It is recognized that the emergence of multicellularity would not have been possible without the formation of the first embryo.
arxiv +1 more source
Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]
, 1987 The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Balcer-Kubiczek E.K. +20 more
core +1 more source
Transformation Locked in a Loop [PDF]
, 2009 During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic ...
Agami, Reuven, Drost, Jarno
core +1 more source
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. [PDF]
PLoS ONE, 2013 Chronic inflammation in the stomach induces metaplasia, the pre-cancerous lesion that precedes inflammation-driven neoplastic transformation. While Hedgehog signaling contributes to the initiation of some cancers, its role in gastric transformation ...
Mohamad El-Zaatari +7 more
doaj +1 more source
Neoplastic transformation of mouse C3H 10T1/2 and Syrian hamster embryo cells by heavy ions [PDF]
, 1989 C3H 10T1/2 mouse-embryo fibroblasts were used for transformation experiments to study the effectiveness of various heavy ions with energies up to 20 MeV/u and LET values from 170 to 16.000 keV/μm.
A.M. Kellerer +24 more
core +1 more source
"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report " [PDF]
Acta Medica Iranica, 2003 Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder.
"Ghavamzadeh A +5 more
doaj +1 more source
The role of E-cadherin in neoplastic evolution of epithelial cells
Успехи молекулярной онкологии, 2015 Interaction of the extracellular domains of the transmembrane proteins cadherins provides cell-cell adhesion. For many years epithelial E- cadherin was regarded as a tumor suppressor and was used as a prognostic marker in cancer.
N. A. Gloushankova +3 more
doaj +1 more source
Study of biomarkers of transformation in cell culture as criteria for assessing the carcinogenic potential of chemicals [PDF]
, 2022 Summary Objectives. Tests for neoplastic cell transformation imitate some of the in vivo steps of multi-stage carcinogenesis process and can detect both genotoxic and non-genotoxic carcinogens in vitro.
Anisovich, M.
core