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Hepatocellular carcinoma arising in a telangiectatic hepatocellular adenoma
Annals of Hepatology, 2013 Telangiectatic hepatocellular adenoma is a rare, recently recognized subtype of benign liver tumor that may very rarely undergo transformation into hepatocellular carcinoma.
María Fernanda González-Lara +4 more
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Spectrum of Sinonasal Lesions with Expression of p16 and Ki-67 in Premalignant Lesions and Squamous Cell Carcinomas [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Sinonasal masses are heterogeneous group of non-neoplastic and neoplastic lesions originating from epithelial, mesenchymal, haematolymphoid and neuroendocrine cells.
Madhumita Paul +3 more
doaj +1 more source
Growth hormone in the tumor microenvironment
Archives of Endocrinology and Metabolism, 2020 Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types.
Vera Chesnokova, Shlomo Melmed
doaj +1 more source
PLoS ONE, 2014 The leucine rich repeats and immunoglobulin-like protein 1 (LRIG1) is a newly discovered negative regulator of epidermal growth factor receptor (EGFR) and a proposed tumor suppressor.
Maho Nagata +5 more
doaj +1 more source
Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele. [PDF]
PLoS ONE, 2012 Animal models which allow the temporal regulation of gene activities are valuable for dissecting gene function in tumorigenesis. Here we have constructed a conditional inducible estrogen receptor-K-ras(G12D) (ER-K-ras(G12D)) knock-in mice allele that ...
Zuoyun Wang +5 more
doaj +1 more source
Nowotwory, 2022 The primary function of intracellular heat shock proteins (HSPs) is to protect the cell by suppressing the effects of various stress factors by either refolding misfolded proteins or blocking apoptosis. After neoplastic transformation, cells overexpress
Iryna Boliukh +2 more
doaj +1 more source
Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line [PDF]
Cancer Research, 2005 Abstract We have described recently a human fibroblast cell line immortalized through ectopic telomerase expression (cen3tel), in which the extension of the life span was associated with the appearance of chromosomal aberrations and with the ability to grow in the absence of solid support.
Zongaro S +5 more
openaire +4 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
STEPS IN THE NEOPLASTIC TRANSFORMATION OF HAMSTER EMBRYO CELLS BY POLYOMA VIRUS [PDF]
Proceedings of the National Academy of Sciences, 1963 Cultures of hamster embryo cells infected with polyoma virus undergo a characteristic transformation within several weeks after infection. The transformed cultures are constituted by highly atypical cells which have an abnormal morphology, grow rapidly in vitro, and give rise to progressively growing tumors when inoculated subcutaneously into the adult
Vogt, Marguerite, Dulbecco, Renato
openaire +3 more sources
Modelling neoplastic progression in epithelial ovarian cancer [PDF]
, 2010 A national screening programme could significantly reduce mortality from epithelial ovarian cancer (EOC). The biological events that occur in the early stages of development of EOCs remain poorly understood, thus hindering the discovery of biomarkers ...
Lawrenson, K.
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