Results 41 to 50 of about 294,511 (213)

S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism

eLife
Lung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated.
Hong Huang, Ying Yang, Qiuju Zhang, Yongfeng Yang, Zhenqi Xiong, Shengqiang Mao, Tingting Song, Yilong Wang, Zhiqiang Liu, Hong Bu, Li Zhang, Le Zhang   +11 more
doaj   +1 more source

Cells With Chromosomal Aberrations Trigger Neoplastic Transformations in Humans [PDF]

Twin Research and Human Genetics, 2016
Human population cytogenetic studies have revealed that a majority of persons who are prone to developing malignant features possess chromatin bodies termed as marker dots (MDs) measuring nearly 2 to 3 microns. These MDs are seen emanating from certain specific chromosomes, which may be early indicators of neoplastic transformation within cells.
openaire   +2 more sources

Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes [PDF]

, 2010
Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division.
Chaplin Tracy, Teh, MT, Muy-Teck Teh, Young Bryan D, Gemenetzidis, E, Teh Muy-Teck, Bryan D Young, Philpott Michael P, Emilios Gemenetzidis, Gemenetzidis Emilios, Chaplin, T, Young, BD, Michael P Philpott, Philpott, MP, Tracy Chaplin   +14 more
core   +1 more source

Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and Sézary Syndrome

Advances in Hematology, 2011
Thymidine phosphorylase may be overexpressed in both neoplastic cells and tumor stromal cells in a variety of malignancies. Our study explores thymidine phosphorylase expression in lymph nodes (LNs) from patients with mycosis fungoides (MF) or Sézary ...
Xingcao Nie, Rekha Bhat, Essel Dulaimi Al-Saleem, Eric C. Vonderheid, J. Steve Hou   +4 more
doaj   +1 more source

A study of energy metabolism in neoplastic cells

, 1990
Some aspects of substrate utilisation by cultured human and rat cells have been investigated.This was achieved by the measurement of maximal enzyme activities and comparison with rates of flux of substrate to products.Substrates examined in detail ...
Board, Mary, Board, M
core   +1 more source

Biomarkers of neoplastic transformation in canine spirocercosis [PDF]

, 2012
Thesis (PhD)--University of Pretoria, 2012.Spirocerca lupi is a nematode that infects the dog’s oesophagus and promotes the formation of an inflammatory fibroblastic nodule that progresses to sarcoma in approximately 25% of cases.

core  

Log₁₀ scale plot of the cancer response activity (CRA) vs. cancer cell type (stage of neoplastic transformation).

, 2017
Log10 scale plot of the cancer response activity (CRA) vs. cancer cell type (stage of neoplastic transformation).
Karin Scarpinato (3710359), Josiah Low (3710356), Tracey Pu (3710353), Daniel Nelli (3710344), Justin Sigley (3710347), Martin Guthold (270306), Keith Bonin (227243), John Jarzen (3710350)   +7 more
core   +1 more source

ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with β-catenin defects and promotes neoplastic transformation

, 2002
In many cancers, inactivation of the adenomatous polyposis coli (APC) or Axin tumor suppressor proteins or activating mutations in β-catenin lead to elevated β-catenin levels, enhanced binding of β-catenin to T cell factor (TCF) proteins, and increased ...
Kathleen R. Cho, Yali Zhai, Gang Hu, Frank T. Kolligs, Nieman, Marvin T., Ian M. Smith, Marvin T. Nieman, Kolligs, Frank T., Zhai, Yali, Rong Wu, Feng, Ying, Eric R. Fearon, Hu, Gang, Cho, Kathleen R., Smith, Ian M., Ying Feng, Wu, Rong, Winer, Ira, Ira Winer, Van Mater, David, David Van Mater, Fearon, Eric R.   +21 more
core   +1 more source

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus [PDF]

, 2010
Background CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level
Young Lawrence S, Elmetwali, Taha, Mcneish, I., Searle Peter F, Young, Lawrence, Searle, PF, Palmer Daniel H, McNeish, I, Young, Lawrence S., Palmer, D.H., McNeish, Iain, Peter F Searle, Lawrence S Young, Elmetwali, T., Searle, P.F., Elmetwali Taha, Iain McNeish, Young, LS, McNeish Iain, Palmer, Daniel H., Palmer, DH, Searle, Peter F., Daniel H Palmer, Young, L.S., Taha Elmetwali, Palmer, Daniel, Searle, Peter, Elmetwali, T   +27 more
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Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity

Epigenetics & Chromatin
Background It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumulation of locally disordered methylation at adjacent CpG sites is involved in neoplastic transformation, acting in similar way as ...
Olga Taryma-Leśniak, Jan Bińkowski, Patrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Konrad Borowski, Tomasz Kazimierz Wojdacz   +5 more
doaj   +1 more source