Results 51 to 60 of about 633,194 (250)
Nowotwory, 2022 The primary function of intracellular heat shock proteins (HSPs) is to protect the cell by suppressing the effects of various stress factors by either refolding misfolded proteins or blocking apoptosis. After neoplastic transformation, cells overexpress
Iryna Boliukh +2 more
doaj +1 more source
A systematic approach to cancer: evolution beyond selection. [PDF]
, 2017 Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems.
Miller, William B, Torday, John S
core +1 more source
Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. [PDF]
, 1987 The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b ...
Hansteen, GA +5 more
core
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells [PDF]
, 2015 The final published version can be found here: http://dx.doi.org/10.1073/pnas ...
Anna Karlsson +18 more
core +1 more source
eLifeLung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated.
Hong Huang +11 more
doaj +1 more source
Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line [PDF]
Cancer Research, 2005 Abstract We have described recently a human fibroblast cell line immortalized through ectopic telomerase expression (cen3tel), in which the extension of the life span was associated with the appearance of chromosomal aberrations and with the ability to grow in the absence of solid support.
Zongaro S +5 more
openaire +4 more sources
The Quest for Targets Executing MYC-Dependent Cell Transformation
Frontiers in Oncology, 2016 MYC represents a transcription factor with oncogenic potential converting multiple cellular signals into a broad transcriptional response, thereby controlling the expression of numerous protein-coding and non-coding RNAs important for cell proliferation,
M. Hartl
semanticscholar +1 more source
Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]
, 2015 BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD +5 more
core
Nonlinear optimization for a tumor invasion PDE model [PDF]
, 2016 In this work, we introduce a methodology to approximate unknown parameters that appear on a non-linear reaction–diffusion model of tumor invasion. These equations consider that tumor-induced alteration of micro-environmental pH furnishes a mechanism for ...
Fernández Ferreyra, Damián Roberto +3 more
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Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]
, 2018 The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B. +2 more
core +3 more sources