Results 61 to 70 of about 6,734,183 (300)

Cell transformation assays for prediction of carcinogenic potential: State of the science and future research needs [PDF]

, 2011
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
R. R. Shen, O'Donovan, MRO, P. L. Carmichael, Schechtman, LM, Aardema, MJ, M. J. Aardema, Tanaka, N, K. Pant, Sakai, A, Scott, AD, Shen, RR, S. Creton, A. Poth, Harvey, JS, Pant, K, M. R. O'Donovan, Creton, S, A. D. Scott, R. F. Newbold, J. S. Harvey, L. M. Schechtman, N. Tanaka, K. Sasaki, Newbold, RF, Yasaei, H, Poth, A, Sasaki, K, A. Sakai, Martin, FL, F. L. Martin, Carmichael, PL, H. Yasaei   +31 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Biomarkers of neoplastic transformation in canine spirocercosis [PDF]

, 2012
Thesis (PhD)--University of Pretoria, 2012.Spirocerca lupi is a nematode that infects the dog’s oesophagus and promotes the formation of an inflammatory fibroblastic nodule that progresses to sarcoma in approximately 25% of cases.

core   +1 more source

Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and Sézary Syndrome

Advances in Hematology, 2011
Thymidine phosphorylase may be overexpressed in both neoplastic cells and tumor stromal cells in a variety of malignancies. Our study explores thymidine phosphorylase expression in lymph nodes (LNs) from patients with mycosis fungoides (MF) or Sézary ...
Xingcao Nie, Rekha Bhat, Essel Dulaimi Al-Saleem, Eric C. Vonderheid, J. Steve Hou   +4 more
doaj   +1 more source

Other title: Office of Children Services Transformation initial findings report

, 2020
"February 2020."; "Mike DeWine, Governor of Ohio; Jon Husted, Lt. Governor of Ohio."; "Ohio Governor's Children's Initiative, Children Services Transformation."; "Safe children. Stable homes.
Ohio. Children Services Transformation Advisory Council
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with β-catenin defects and promotes neoplastic transformation [PDF]

, 2002
In many cancers, inactivation of the adenomatous polyposis coli (APC) or Axin tumor suppressor proteins or activating mutations in β-catenin lead to elevated β-catenin levels, enhanced binding of β-catenin to T cell factor (TCF) proteins, and increased ...
Kathleen R. Cho, Yali Zhai, Gang Hu, Frank T. Kolligs, Nieman, Marvin T., Ian M. Smith, Marvin T. Nieman, Kolligs, Frank T., Zhai, Yali, Rong Wu, Feng, Ying, Eric R. Fearon, Hu, Gang, Cho, Kathleen R., Smith, Ian M., Ying Feng, Wu, Rong, Winer, Ira, Ira Winer, Van Mater, David, David Van Mater, Fearon, Eric R.   +21 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cells With Chromosomal Aberrations Trigger Neoplastic Transformations in Humans [PDF]

Twin Research and Human Genetics, 2016
Human population cytogenetic studies have revealed that a majority of persons who are prone to developing malignant features possess chromatin bodies termed as marker dots (MDs) measuring nearly 2 to 3 microns. These MDs are seen emanating from certain specific chromosomes, which may be early indicators of neoplastic transformation within cells.
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source