Results 31 to 40 of about 294,511 (213)

Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line [PDF]

Cancer Research, 2005
Abstract We have described recently a human fibroblast cell line immortalized through ectopic telomerase expression (cen3tel), in which the extension of the life span was associated with the appearance of chromosomal aberrations and with the ability to grow in the absence of solid support.
Zongaro S, de Stanchina E, Colombo T, D'Incalci M, Giulotto E, Mondello C   +5 more
openaire   +4 more sources

Growth hormone in the tumor microenvironment

Archives of Endocrinology and Metabolism, 2020
Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types.
Vera Chesnokova, Shlomo Melmed
doaj   +1 more source

Long-term cultivation of two diploid epithelial cell lines derived from normal rat liver cells

, 1974
To obtain a useful rat liver cell line for in vitro carcinogenesis, two rat diploid epithelial cell lines were established from a 7-day-old male rat by the repeated colonial clone method.
Nakabayashi, Hidekazu, Masuji, Hiroshi, Sato, Jiro   +2 more
core   +1 more source

LRIG1 as a potential novel marker for neoplastic transformation in ocular surface squamous neoplasia.

PLoS ONE, 2014
The leucine rich repeats and immunoglobulin-like protein 1 (LRIG1) is a newly discovered negative regulator of epidermal growth factor receptor (EGFR) and a proposed tumor suppressor.
Maho Nagata, Takahiro Nakamura, Chie Sotozono, Tsutomu Inatomi, Norihiko Yokoi, Shigeru Kinoshita   +5 more
doaj   +1 more source

Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele. [PDF]

PLoS ONE, 2012
Animal models which allow the temporal regulation of gene activities are valuable for dissecting gene function in tumorigenesis. Here we have constructed a conditional inducible estrogen receptor-K-ras(G12D) (ER-K-ras(G12D)) knock-in mice allele that ...
Zuoyun Wang, Yan Feng, Nabeel Bardeesy, Kwok-Kin Wong, Xin-Yuan Liu, Hongbin Ji   +5 more
doaj   +1 more source

Immunological aspects of heat shock protein functions and their significance in the development of cancer vaccines

Nowotwory, 2022
The primary function of intracellular heat shock proteins (HSPs) is to protect the cell by suppressing the effects of va­rious stress factors by either refolding misfolded proteins or blocking apoptosis. After neoplastic transformation, cells overexpress
Iryna Boliukh, Agnieszka Rombel-Bryzek, Barbara Radecka   +2 more
doaj   +1 more source

Basic methodology for cell culture--cell transformation

, 1974
The word "transformation" is used to describe the permanent acquisition of new characters by cultured cells. Of the many different types of transformation that are known, the best studied is neoplastic transformation.
Joseph Sambrook, Pollack, R., Sambrook, J., Robert Pollack, Sambrook, Joseph, Pollack, Robert   +5 more
core   +1 more source

Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation [PDF]

, 2009
Background: Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells are not. The E1A gene determines
Strath, Janet, Strath Janet, Kellam, P., Blair G Eric, Janet Strath, Strath, J., Paul Kellam, Georgopoulos, L.J., Georgopoulos, Lindsay J, G Eric Blair, Kellam, Paul, Blair, G Eric, Lindsay J Georgopoulos, Georgopoulos Lindsay J, Blair, G.E., Kellam Paul   +15 more
core   +1 more source

Neoplastic transformation of a human hybrid cell line by alpha particles in relation to mammography X rays

, 2006
The hybrid cell line CGL1 is the only cell line which allows quantitation of neoplastic transformation in human cells. Hybrid cells were exposed to 3.4 MeV alpha particles or to mammography X rays (29 kV(p)) and both survival and neoplastic cell ...
Frankenberg-Schwager, Marlis, Pralle, Elke, Spieren, S., Frankenberg, Dieter   +3 more
core   +1 more source

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair [PDF]

, 2011
Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that ...
Palmarini, M., Ferri, N., Varasano Vincenzo, Murgia, C., Murgia C., Palmarini M., Vincenzo Varasano, Varasano, V., de las Heras Marcelo, Ceesay O., Marcelo de las Heras, Ferri Nicola, Caporale Marco, Di Francesco Gabriella, de las Heras M., Ceesay, O., Murgia Claudio, Palmarini Massimo, Nicola Ferri, Varasano V., de las Heras, M., Di Francesco G., Ousman Ceesay, Ferri N., Marco Caporale, Massimo Palmarini, Caporale M., Di Francesco, G., Gabriella Di Francesco, Claudio Murgia, Ceesay Ousman, Caporale, M.   +31 more
core   +1 more source