Effects of Curcumin on Sodium Arsenite Induced Neoplastic Cell Transformation in Balb/c 3T3 Cells [PDF]
Brazilian Archives of Biology and Technology, 2021 HIGHLIGHTS Sodium arsenite can cause neoplastic transformation in cells. Curcumin reduced cell viability and increased LDH activity in transformed Balb/c 3T3 cells. Curcumin caused DNA damage in transformed Balb/c 3T3 cells.
Busra Demircioglu +4 more
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Mechanisms of radiation-induced neoplastic cell transformation [PDF]
, 1984 Studies with cultured mammalian cells demonstrated clearly that radiation can transform cells directly and can enhance the cell transformation by oncogenic DNA viruses. In general, high-LET heavy-ion radiation can be more effective than X and gamma rays in inducing neoplastic cell transformation.
Yang, T. C. H., Tobias, C. A.
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eLife, 2021 Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock +9 more
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Nature Communications, 2021 The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi +19 more
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Elastic Moduli of Cells undergoing Neoplastic Transformation [PDF]
Biophysical Journal, 2013 Using an Atomic Force Microscope (AFM) with a 5.3 um diameter spherical probe we determined the elastic modulus of human mammary epithelial cells (HMEC) as they undergo neoplastic transformation from normal to immortal, tumorigenic, and finally metastatic. We did the measurements over both cytoplasmic and nuclear regions; and as a function of the cells
Guo, Xinyi +2 more
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Clinicopathologic characteristics of ovarian clear cell carcinoma in the background of endometrioma: a surveillance strategy for an early detection of malignant transformation in patients with asymptomatic endometrioma [PDF]
Obstetrics & Gynecology Science, 2019 ObjectiveThis study aimed to analyze the clinical features of clear cell carcinoma in relation to endometriosis and to determine an appropriate surveillance strategy for the early detection of malignant transformation of endometrioma in asymptomatic ...
Joo-Hyuk Son +6 more
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The impact of molecular alterations and the immune microenvironment on the natural history of Follicular Lymphoma including transformation to Diffuse Large B cell Lymphoma [PDF]
, 2009 PhDThe natural history of follicular lymphoma is heterogeneous with numerous relapses and remissions over many years. A substantial number of patients suffer an aggressive disease course with death due to disease within 5 years of diagnosis.
Lee, Abigail Mary
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Alternative Splicing and Its Impact as a Cancer Diagnostic Marker [PDF]
Genomics & Informatics, 2012 Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions.
Yun-Ji Kim, Heui-Soo Kim
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Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation. [PDF]
PLoS ONE, 2015 Comprehensive analysis of alterations in gene expression along with neoplastic transformation in human cells provides valuable information about the molecular mechanisms underlying transformation.
Masao Takeuchi +13 more
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Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]
, 1987 The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Fenn, S. +5 more
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