Results 11 to 20 of about 633,194 (250)

Alternative Splicing and Its Impact as a Cancer Diagnostic Marker [PDF]

Genomics & Informatics, 2012
Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions.
Yun-Ji Kim, Heui-Soo Kim
doaj   +1 more source

Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation. [PDF]

PLoS ONE, 2015
Comprehensive analysis of alterations in gene expression along with neoplastic transformation in human cells provides valuable information about the molecular mechanisms underlying transformation.
Masao Takeuchi, Atsunori Higashino, Kikuko Takeuchi, Yutaro Hori, Kazuko Koshiba-Takeuchi, Hatsune Makino, Yoko Monobe, Marina Kishida, Jun Adachi, Jun Takeuchi, Takeshi Tomonaga, Akihiro Umezawa, Yosuke Kameoka, Ken-Ichi Akagi   +13 more
doaj   +1 more source

Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]

, 1987
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Balcer-Kubiczek E.K., Barendsen G.W, Barendsen G.W., Borek C., Burch P.R.J., Elkind M.M., Hall E.J., Han A., Han A., Hill C.K., Hill C.K., Hill C.K., Lloyd E.L., Miller R.C., Miller R.C., Reznikoff C., Robertson J.B., Roos H., Rossi H.H., Terzaghi M., Yang T.   +20 more
core   +1 more source

PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth

OncoTarget, 2016
The fucoidan with high anticancer activity was isolated from brown alga Fucus evanescens. The compound effectively prevented EGF-induced neoplastic cell transformation through inhibition of TOPK/ERK1/2/MSK 1 signaling axis.
Olesia S. Vishchuk, Huimin Sun, Zhe Wang, S. Ermakova, Juanjuan Xiao, T. Lu, Peipei Xue, T. Zvyagintseva, H. Xiong, C. Shao, Wei Yan, Q. Duan, Feng Zhu   +12 more
semanticscholar   +1 more source

An aggressive verrucous carcinoma of the palate with rare presentations and recurrence: A case report and literature review [PDF]

Journal of Oral Health and Oral Epidemiology, 2020
BACKGROUND AND AIM: Oral verrucous carcinoma (OVC) is a rare malignant tumor with a complex etiology. This tumor is more prevalent in men and buccal mucosa is the most common site of OVC.
Sahar Mafi, Nader Navabi, Mahsa Kalantari   +2 more
doaj   +1 more source

Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation

Cell Death Discovery, 2019
Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs that causes tissue damage and may promote tumorigenesis.
N. Rainey, A. Moustapha, A. Šariċ, G. Nicolas, F. Sureau, P. Petit   +5 more
semanticscholar   +1 more source

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. [PDF]

PLoS ONE, 2013
Chronic inflammation in the stomach induces metaplasia, the pre-cancerous lesion that precedes inflammation-driven neoplastic transformation. While Hedgehog signaling contributes to the initiation of some cancers, its role in gastric transformation ...
Mohamad El-Zaatari, John Y Kao, Art Tessier, Longchuan Bai, Michael M Hayes, Clinton Fontaine, Kathryn A Eaton, Juanita L Merchant   +7 more
doaj   +1 more source

Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. [PDF]

, 2015
The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental
Bosco MC, Cabodi S, Donnini S, Eva A., Finetti F, MANCINI, Patrizia, Ognibene M, Segalerba D, TORRISI, Maria Rosaria, Vanni C, Varesio L   +10 more
core   +1 more source

"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report " [PDF]

Acta Medica Iranica, 2003
Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder.
"Ghavamzadeh A, Alimoghaddam K, Mehdipour P, Sharifian R, Schwanitz G, Shamshiri AR "   +5 more
doaj   +1 more source

Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells.
Dhall, Deepti, Greene, Mark I, Morvaridi, Susan, Pandol, Stephen J, Wang, Qiang   +4 more
core   +1 more source