Results 81 to 90 of about 593,168 (347)
Radiation-induced neoplastic transformation of human cells.
Scanning microscopy, 1993 Ionizing radiation can induce cancers in humans and animals and can cause in vitro neoplastic transformation of various rodent cell systems. However, numerous attempts to achieve neoplastic transformation of human cells by radiation have generally proven unsuccessful.
Rhim, J. S. +4 more
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Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development
Advanced Science, EarlyView.Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong +21 more
wiley +1 more source
Cells With Chromosomal Aberrations Trigger Neoplastic Transformations in Humans [PDF]
Twin Research and Human Genetics, 2016 Human population cytogenetic studies have revealed that a majority of persons who are prone to developing malignant features possess chromatin bodies termed as marker dots (MDs) measuring nearly 2 to 3 microns. These MDs are seen emanating from certain specific chromosomes, which may be early indicators of neoplastic transformation within cells.
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Genes & Development, 2009 Pancreatic ductal adenocarcinoma (PDAC) is characterized by the deregulation of the hedgehog signaling pathway. The Sonic Hedgehog ligand (Shh), absent in the normal pancreas, is highly expressed in pancreatic tumors and is sufficient to induce ...
Olivier Nolan-Stevaux +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo +18 more
wiley +1 more source
Transformation of benign phyllodes to malignant phyllodes tumor
Medicina, 2015 Importance of the problem: Malignant phyllodes tumors are rare fibroepithelial neoplasm in which clinical findings remain insufficient to determine a proper preoperative diagnoses and therefore has an unpredictable clinical outcome for optimal treatment.
Adrienne Pratti Lucarelli +3 more
doaj +1 more source
eJHaem, 2022 This report highlights the value of flow cytometry analysis, particularly in the setting of myeloproliferative neoplasms showing features of progression, as neoplastic plasmacytoid dendritic cell (PDC) proliferations may be present, representing either a
Siba El Hussein +11 more
doaj +1 more source
A case report of a rare intramuscular granular cell tumor [PDF]
, 2015 Background: Granular cell tumors (GCTs) were firstly described by Weber in 1854 and 70 years later by Abrikossoff and classified as benign tumors. Originally considered muscle tumors, they have been identified as neural lesions, due to their close ...
Cacciotti, Jessica +8 more
core +1 more source
Advanced Science, EarlyView.Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan +11 more
wiley +1 more source
Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B [PDF]
Scientific Reports, 2019 AbstractBone marrow stromal (Mesenchymal) stem cells (MSCs) are multipotent bone cells capable of differentiating into mesoderm-type cells, such as osteoblasts and adipocytes. Existing evidence suggests that transformation of MSCs gives rise to sarcoma.
Radhakrishnan Vishnubalaji +12 more
openaire +6 more sources