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The effect of virus-induced cellular transformation on oncogenesis [PDF]

Наука и инновации в медицине, 2023
Aim to summarize the scientific data presented in the recent publications on tumor-associated processes induced by viruses. We analyzed 23 international publications devoted to the development and course of tumor-related processes associated with ...
Aleksandr V. Moskalev, Boris Yu. Gumilevsky, Aleksandr V. Zhestkov, Maksim O. Zolotov   +3 more
doaj   +1 more source

Dendrosomal nanocurcumin prevents EBV-associated cell transformation by targeting the lytic cycle genes of the Epstein-Barr virus in the generation of lymphoblastoid cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Targeting the lytic cycle of the Epstein-Barr virus (EBV) has been considered a new treatment strategy for malignancies caused by this virus.
Mahboobeh Cheragh, Majid Sadeghizadeh, Mohammad Hasan Pouriayevali, Masoud Parsania   +3 more
doaj   +1 more source

Protein Kinase CK2 and Epstein–Barr Virus

Biomedicines, 2023
Protein kinase CK2 is a pleiotropic protein kinase, which phosphorylates a number of cellular and viral proteins. Thereby, this kinase is implicated in the regulation of cellular signaling, controlling of cell proliferation, apoptosis, angiogenesis ...
Mathias Montenarh, Friedrich A. Grässer, Claudia Götz   +2 more
doaj   +1 more source

Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation. [PDF]

PLoS ONE, 2011
High risk human papillomaviruses are squamous epitheliotropic viruses that may cause cervical and other cancers. HPV replication depends on squamous epithelial differentiation.
Svetlana Vinokurova, Magnus von Knebel Doeberitz   +1 more
doaj   +1 more source

SV40 miR-S1 and Cellular miR-1266 Sequester Each Other from Their Targets, Enhancing Telomerase Activity and Viral Replication

Non-Coding RNA, 2022
Virus-encoded microRNAs (miRNAs) target viral and host mRNAs to repress protein production from viral and host genes, and regulate viral persistence, cell transformation, and evasion of the immune system.
Tetsuyuki Takahashi, Hirona Ichikawa, Yukiko Okayama, Manami Seki, Takao Hijikata   +4 more
doaj   +1 more source

Viral Agents as Potential Drivers of Diffuse Large B-Cell Lymphoma Tumorigenesis

Viruses, 2022
Among numerous causative agents recognized as oncogenic drivers, 13% of total cancer cases occur as a result of viral infections. The intricacy and diversity of carcinogenic processes, however, raise significant concerns about the mechanistic function of
Esma Bilajac, Lejla Mahmutović, Kenneth Lundstrom, Una Glamočlija, Jasmin Šutković, Abas Sezer, Altijana Hromić-Jahjefendić   +6 more
doaj   +1 more source

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
A Bianchini, A Villanueva, Alexandra Junger, Antonia Rizzani, DA Altomare, EF Dunn, Enrico N. De Toni, Günter Schneider, HG Wendel, I Fabregat, I Nicoletti, IBCJ Rosenwald, JE Dancey, Jennifer Altomonte, JH Connor, JS Orlando, K Shinozaki, K Shinozaki, L Mishra, LM Schang, M Ahmed, M Hidalgo, M Ikeda, M Sun, Maciej Lesniak, N Kato, N Kato, N Kemeny, N Sonenberg, NA Hamid, Nobuyuki Kato, O Ebert, O Ebert, O Larsson, Oliver Ebert, P Chakraborty, P Newell, PC Chiang, PL Hallenbeck, RB Kjellerup, RL Silva, RM Memmott, Roland M. Schmid, S Balachandran, S Joshi, S Marozin, S Oliere, S Sei, S Sell, Sabrina Marozin, SM Steinberg, SR Kimball, T Cascone, T Nakamura, T Ueda, TL Nguyen, TP Cripe, WE Thasler, Wolfgang E. Thasler, XQ Lun, Y Ma   +60 more
core   +7 more sources

Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters [PDF]

, 2014
Shaojie Zhang, Vojtech Sroller, Preeti Zanwar, Steven J. Halvorson, Nadim J. Ajami, Corey W. Hecksel, Jody L. Swain, Connie Wong, Janet S. Butel, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States
Ajami, Nadim J., Butel, Janet S., Chen, Chun Jung, Halvorson, Steven J., Hecksel, Corey W., Sroller, Vojtech, Sullivan, Christopher S., Swain, Jody L., Wong, Connie, Zanwar, Preeti, Zhang, Shaojie   +10 more
core   +15 more sources

Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytes

Scientific Reports, 2023
Infection with high-risk human papillomaviruses like HPV-16 and HPV-18 is highly associated with the development of cervical and other cancers. Malignant transformation requires viral oncoproteins E5, E6 and E7, which promote cell proliferation and ...
Jimena Hochmann, Magdalena Millán, Paola Hernández, Laura Lafon-Hughes, Natali D’ Aiuto, Alejandro Silva, Juan Llaguno, Julia Alonso, Ariel Fernández, Vanesa Pereira-Prado, José Sotelo-Silveira, Ronell Bologna-Molina, Miguel Arocena   +12 more
doaj   +1 more source

Autophagy in Human T-Cell Leukemia Virus Type 1 (HTLV-1) Induced Leukemia

Frontiers in Oncology, 2021
Viruses play an important role in the development of certain human cancers. They are estimated to contribute 16% to all human cancers. Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus to be discovered and is the etiological ...
Nicolás Ducasa, Daniel Grasso, Daniel Grasso, Paula Benencio, Daniela L. Papademetrio, Daniela L. Papademetrio, Mirna Biglione, Fatah Kashanchi, Carolina Berini, Maria Noé Garcia, Maria Noé Garcia   +10 more
doaj   +1 more source