Results 21 to 30 of about 6,985,466 (303)

PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival

Viruses, 2015
Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia/lymphoma (ATLL). This disease manifests after a long clinical latency period of up to 2–3 decades.
Amanda R. Panfil, Jacob Al-Saleem, Cory M. Howard, Jessica M. Mates, Jesse J. Kwiek, Robert A. Baiocchi, Patrick L. Green   +6 more
doaj   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

Viral interferon antagonists and antiviral drugs [PDF]

, 2009
For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core   +2 more sources

Oncogenic viruses and their role in tumor formation [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2005
Oncogenic viruses trigger persistent infections, which can stimulate uncontrolled cell growth by inducing cell transformation. Different oncogenic viruses use different mechanisms for infecting cells.
Ćupić Maja, Lazarević Ivana, Kuljić-Kapulica Nada   +2 more
doaj   +1 more source

Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes

Viruses, 2021
The adenovirus type 5 (HAdV-C5) E1 transcription unit encodes regulatory proteins that are essential for viral replication and transformation. Among these, E1A and E1B-55K act as key multifunctional HAdV-C5 proteins involved in various steps of the viral
Wing-Hang Ip, Britta Wilkens, Anastasia Solomatina, Judith Martin, Michael Melling, Paloma Hidalgo, Luca D. Bertzbach, Thomas Speiseder, Thomas Dobner   +8 more
doaj   +1 more source

The Role of microRNAs, Long Non-coding RNAs, and Circular RNAs in Cervical Cancer

Frontiers in Oncology, 2020
Prolonged infection of uterine cervix epithelium with human papillomavirus (HPV) and constitutive expression of viral oncogenes have been recognized as the main cause of the complex molecular changes leading to transformation of cervical epithelial cells.
Maria Lina Tornesello, Raffaella Faraonio, Luigi Buonaguro, Clorinda Annunziata, Noemy Starita, Andrea Cerasuolo, Francesca Pezzuto, Anna Lucia Tornesello, Franco Maria Buonaguro   +8 more
doaj   +1 more source

The eEF1A proteins: at the crossroads of oncogenesis, apoptosis and viral infections.

Frontiers in Oncology, 2015
Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors, but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer and lung cancer.
Georges eHerbein, Wasim eAbbas, Amit eKumar   +2 more
doaj   +1 more source

The Integrated State of Viral DNA in SV40-Transformed Cells [PDF]

Proceedings of the National Academy of Sciences, 1968
It has been shown by a modified DNA-RNA hybridization technique that the nuclei of cells transformed by either polyoma virus or SV40 contain viral DNA.1 This method employs RNA synthesized in vitro with form I viral DNA2–4 and E. coli RNA polymerase. The number of viral DNA equivalents per cell varies from 5 to 60, depending on the cell line.
J, Sambrook, H, Westphal, P R, Srinivasan, R, Dulbecco   +3 more
openaire   +2 more sources

The potato mop-top virus TGB2 protein and viral RNA associate with chloroplasts and viral infection induces inclusions in the plastids [PDF]

, 2012
The potato mop-top virus (PMTV) triple gene block 2 (TGB2) movement proteins fused to monomeric red fluorescent protein (mRFP-TGB2) was expressed under the control of the PMTV subgenomic promoter from a PMTV vector.
Roberts, Alison G., Cowan, Graham H., Angelika eZiegler, Ziegler, Angelika, Eugene I Savenkov, Lesley eTorrance, Angelika Ziegler, Lesley Torrance, Alison G Roberts, Torrance, Lesley, Sean N. Chapman, Graham H Cowan, Chapman, Sean N., Savenkov, Eugene I., Sean N Chapman, Alison G. Roberts, Chapman, Sean, Graham H. Cowan, Eugene I. Savenkov, Savenkov, Eugene, Sveriges lantbruksuniversitet., Savenkov, Eugene,   +21 more
core   +1 more source

Liver Cell Transformation in Chronic HBV Infection

Viruses, 2009
Epidemiological studies have provided overwhelming evidence for a causal role of chronic HBV infection in the development of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying virally-induced tumorigenesis remain largely debated.
Marie Annick Buendia, Delphine Cougot, Shirine Benhenda, Christine Neuveut   +3 more
doaj   +1 more source