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Viral Transformation of Epithelial Cells
2012Approximately 18% of human cancers have a viral etiology and the majority of these involve transformation of epithelial cells. Viral proteins transform epithelia by inducing alterations in the normal cell growth and differentiation pathways through the targeting of host proteins.
Jennifer A, Regan, Laimonis A, Laimins
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Cell Transformation by the Viral src Oncogene
Annual Review of Cell Biology, 1987PERSPECTIVES AND SUMMARy . .... . . ... ......... . . . . . . . . .. . . . . 31 OVERVIEW OF CELL TRANSFORMATION . .. ..... . ......... . . .. ". . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 ORIGIN OF VIRAL src . ..... ..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .....
R, Jove, H, Hanafusa
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The viral genome in transformed cells
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1971Abstract Polyoma and SV 40-transformed cells carry multiple copies of the entire genome in their chromosomes; the viral DNA sequences appear to be covalently integrated into the host cell’s DNA but it is not known whether they are clustered in a reiterated tandem sequence or whether they are distributed singly or in clusters ...
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Cell-Driven Viral Transformation
1985Since the advent of hybridoma technology, one of the most provocative applications for monoclonal antibodies has been immunotherapy. Early reports of experiments performed in mice suggested that monoclonal antibody therapy was beneficial against murine T-cell lymphoma (Bernstein et al., 1980) and that it might be useful to deliver potent toxins to ...
Anthony W. Siadak, Mark E. Lostrom
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Increment of DNA topoisomerases in chemically and virally transformed cells
Experimental Cell Research, 1988The activities of topoisomerases I and II were assayed in subcellular extracts obtained from nontumorigenic BALB/c 3T3 A31 and normal rat kidney (NRK) cell lines and from the same cells transformed by benzo[a]pyrene (BP-A31), Moloney (M-MSV-A31) and Kirsten (K-A31) sarcoma viruses, and simian virus 40 (SV-NRK). The enzymatic activity of topoisomerase I
M D, Crespi, A G, Mladovan, A, Baldi
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Viral Transformation of Monkey Kidney Cell Cultures
Nature, 1967Simian tumour virus SV40 induces transformation of primary cultures of cercopithecus monkey kidney cells. The cells become highly vacuolated, complement fixing viral antigen is formed and the cells become resistant to the cytopathic effects of the virus. It is probable that a persistent association develops between the cells and the virus genome.
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SELECTIVE KILLING OF TRANSFORMED CELLS BY A VIRAL CYTOTOXIC PRODUCT
Biochemical Society Transactions, 1996info:eu-repo/semantics ...
Mousset, Suzanne +3 more
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