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An altered response of virally transformed 3T3 cells to ouabain
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1978The effect of ouabain on K+ transport was examined in 3T3 and virally transformed 3T3 cells. A 10 min exposure to ouabain (10(-3) M) produced approximately 40% inhibition of the unidirectional K+ influx in all cell lines. In 3T3 cells the response was not significantly altered by up to 70 min exposure to the drug. In contrast, the continued exposure of
K D, Brown, J F, Lamb
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On the reduced intercellular adhesiveness of virally transformed BHK21 cells
Journal of Cell Science, 1979ABSTRACT Baby hamster kidney fibroblasts (BHK21 cells) transformed by polyoma or Rous sarcoma viruses aggregate less than the untransformed parental cells when incubated in growth medium in a gyratory shaker for 18–24 h. This difference can be measured by electronic particle counting, or by filtering aggregated suspensions of 32 P ...
J G, Edwards +3 more
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Proteolytic Enzymes, Cell Surface Changes, and Viral Transformation
1976Publisher Summary This chapter reviews the evidence for and against the view that proteolysis plays a role in determining some of the phenotypic characteristics of virus-transformed cells. It discusses some aspects of the structure of the cellular membrane surface because one possible mechanism by which proteases might alter cell properties is via ...
R, Robin, I N, Chou, P H, Black
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Stability of p53 protein in rat cells transformed by various viral transforming genes
Virology, 1992To clarify the correlation between metabolic stabilization of p53 protein and cellular transformation, we transformed the normal rat cell line F2408 with various viral transforming genes and examined the expression and stability of p53 protein in these transformed cells by pulse-chase immunoprecipitation experiments.
H, Inoue +3 more
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Gangliosides of chemically and virally transformed rat embryo cells
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975The gangliosides of control rat embryo cells, 3-methylcholanthrene, Rauscher leukemia virus, and combined 3-methylcholanthrene-Rauscher leukemia virus transformants were examined using [14 C]glucosamine as a tracer. All four cell lines exhibited a complex pattern of gangliosides.
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Further study of β‐tgfs released by virally transformed and non‐transformed cells
International Journal of Cancer, 1985AbstractChicken embryo fibroblasts sensitized by ts RSV respond to TGFs present in the media of non‐transformed FR3T3 and NRK‐4 rat cells and of the same cells transformed by KiMSV or RSV. They also respond to TGFs present in the media of BHK hamster cells transformed by MoMSV, PyV or RSV.
C, Krycève-Martinerie +4 more
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The effect of viral transformation on prostaglandin production depends on cell type
Virology, 1986The role of prostaglandins in cellular differentiation and transformation has been widely studied. We have found previously that prostaglandin E2 production was greatly diminished in dog kidney cells (MDCK) after transformation by Harvey murine sarcoma virus.
Lin, MC, Segawa, K, Ito, Y, Beckner, SK
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State of viral DNA in BK virus-transformed rabbit cells
Virology, 1980Abstract Semipermissive rabbit liver, brain, and kidney cells were transformed by BK virus (BKV). All cells of the three resulting cell lines produced BKV T antigen. Viral DNA was detected by DNA-DNA reassociation kinetics and by blot-transfer hybridization.
Chenciner N. +6 more
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Biochemical characteristics of normal and virally transformed mouse cell lines
Journal of Cellular Physiology, 1972AbstractNormal and virally transformed mouse cells respond differently in vitro to high concentrations of potassium. A higher potassium concentration is required to inhibit multiplication of SV40 transformed 3T3 cells to the same extent as that of normal 3T3 cells.
M, Yoshikawa-Fukada, T, Nojima
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