Results 41 to 50 of about 326,716 (261)

The ACBD3 protein coordinates ER-Golgi contacts to enable productive TBEV infection

Journal of Virology
Flavivirus infection involves extensive remodeling of the endoplasmic reticulum (ER), which is key to both the replication of the viral RNA genome as well as the assembly and release of new virions.
Wai-Lok Yau, Marie B. A. Peters, Sebastian Rönfeldt, Marie N. Sorin, Richard Lindqvist, Lauri I. A. Pulkkinen, Lars-Anders Carlson, Anna K. Överby, Richard Lundmark   +8 more
doaj   +1 more source

Protein transduction: A novel tool for tissue regeneration [PDF]

, 2002
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W., Han K., Ho A., Park J., Theodore L.   +4 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Epstein-Barr virus infectious particles initiate B cell transformation and modulate cytokine response

mBio, 2023
The Epstein-Barr virus (EBV) efficiently transforms primary B cells. Here, we show that this process starts immediately after cellular exposure to infectious viral particles.
Francesco Baccianti, Charlène Masson, Susanne Delecluse, Zhe Li, Remy Poirey, Henri-Jacques Delecluse   +5 more
doaj   +1 more source

Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]

, 2015
Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric, Biffoni, Mauro, Chung, Hye Kyung, Farrell, Nicholas, Labranche, Celia, Lewis, Mark G., Montefiori, David, Nickel, Gabrielle, Pal, Ranajit, PALAMARA, ANNA TERESA, Robert Guroff, Marjorie, Sacha, Jonah B., Savarino, Andrea, Shytaj, Iart Luca, Vargas Inchaustegui, Diego   +14 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes, Aoyama, Barak, Bressac, Bressac, Buetow, Caselmann, Challen, Colombo, Donehower, Fields, Finlay, Foster, Halevy, Hsu, Jenkins, Kastan, Kekulé, Kew, Kress, Lane, Laurent-Puig, Lilleberg, Livingstone, Ludlow, Malkin, Marshall, Meyer, Meyer, Mueller, Murakami, Nigro, Ozturk, Raycroft, Sarnow, Slagle, Srivastava, Sturzbecher, Taylor, Wolfgang H. Caselmann, Wollersheim   +40 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Morphology and ultrastructure of retrovirus particles

AIMS Biophysics, 2015
Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the host plasma membrane, acquisition of the viral membrane and envelope proteins through budding, and formation of the core through the maturation process.
Wei Zhang, Sheng Cao, Jessica L. Martin, Joachim D. Mueller, Louis M. Mansky   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source