Results 51 to 60 of about 6,985,466 (303)

Autophagy in Viral Development and Progression of Cancer

Frontiers in Oncology, 2021
Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases.
Alejandra Suares, Alejandra Suares, María Victoria Medina, María Victoria Medina, Omar Coso, Omar Coso   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Hepatitis virus-associated B cell non-Hodgkin’s lymphoma involves dysregulated epigenetic and RNA-mediated regulatory gene expression and altered snoRNA transcription

Scientific Reports
Infection with HBV and its satellite virus HDV remain a significant global health issue due to their involvement in hepatic and extrahepatic diseases, including B cell non-Hodgkin’s lymphoma (BNHL).
Amanda N. Henning, Myagmarjav Budeebazar, Delgerbat Boldbaatar, Dahgwahdorj Yagaanbuyant, Davaadorj Duger, Khishigjargal Batsukh, Samantha Muccilli, Jordan Pardoe, Lara Perinet, Olivia Conway, Darryl Owusu-Ansah, Kobe Robichaux, Ryan Baumann, Harvey J. Alter, Naranjargal Dashdorj, Valeria De Giorgi   +15 more
doaj   +1 more source

Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis [PDF]

Proceedings of the National Academy of Sciences, 1973
Putative cell-surface proteins of tissue-culture cells were identified by lactoperoxidase-catalyzed iodination, a technique that attaches label only to proteins outside the cell membrane. Evidence is presented that these proteins are cell derived, not contaminating serum proteins.
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The ACBD3 protein coordinates ER-Golgi contacts to enable productive TBEV infection

Journal of Virology
Flavivirus infection involves extensive remodeling of the endoplasmic reticulum (ER), which is key to both the replication of the viral RNA genome as well as the assembly and release of new virions.
Wai-Lok Yau, Marie B. A. Peters, Sebastian Rönfeldt, Marie N. Sorin, Richard Lindqvist, Lauri I. A. Pulkkinen, Lars-Anders Carlson, Anna K. Överby, Richard Lundmark   +8 more
doaj   +1 more source

Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance.

PLoS Pathogens, 2022
Merkel cell polyomavirus (MCV) is a small DNA tumor virus that persists in human skin and causes Merkel cell carcinoma (MCC) in immunocompromised individuals.
Kyle Rapchak, Shiva D Yagobian, Jackson Moore, Michelle Khattri, Masahiro Shuda   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Human polyomaviruses and cancer: an overview

Clinics, 2018
The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the
José Carlos Mann Prado, Telma Alves Monezi, Aline Teixeira Amorim, Vanesca Lino, Andressa Paladino, Enrique Boccardo   +5 more
doaj   +1 more source