Results 231 to 240 of about 1,789,995 (350)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

ARID1A silencing-mediated upregulation of microRNA-652 accelerates cigarette smoke-induced human bronchial epithelial cell transformation by targeting ZFAND5. [PDF]

BMC Pulm Med
Zhang KL, Wu DN, Chen RH, Zheng C, Huang RS, Zhao XD.   +5 more
europepmc   +1 more source

Small-cell lung cancer with a rare epidermal growth factor receptor gene mutation showing “wax-and-wane” transformation [PDF]

, 2013
Yusuke Takagi, Yoshiro Nakahara, Yukio Hosomi, Tsunekazu Hishima   +3 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression. [PDF]

Front Physiol
Mahapatra C, Kishore A, Gawad J, Al-Emam A, Kouzeiha RA, Rusho MA.   +5 more
europepmc   +1 more source

The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants

, 2009
Byung Min Chung, Manjari Dimri, Manju George, Alagarsamy Lakku Reddi, G Chen, Vimla Band, Hamid Band   +6 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis. [PDF]

J Neuroinflammation
Wang L, Ouyang D, Li L, Cao Y, Wang Y, Gu N, Zhang Z, Li Z, Tang S, Tang H, Zhang Y, Sun X, Yan J.   +12 more
europepmc   +1 more source

Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes

Yi‐Chun Huang, Caique Almeida Machado Costa, Nicolas Vergara Ruiz, Xianfeng Wang, Allison Jevitt, Christina Marie Breneman, Chun Han, Wu‐Min Deng   +7 more
openalex   +1 more source

Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells

, 2008
Christos Tsatsanis, Katerina Vaporidi, Vassiliki Zacharioudaki, Ariadne Androulidaki, Yuri Sykulev, Andrew N. Margioris, Philip N. Tsichlis   +6 more
openalex   +1 more source