Results 101 to 110 of about 9,650,343 (306)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through regulating miRNAs

, 2012
[[abstract]]"The epithelial-mesenchymal transition (EMT) has recently been linked to stem cell phenotype. However, the molecular mechanism underlying EMT and regulation of stemness remains elusive.
;Liu, M.;Chen, C-T.;Yu, D.;洪明奇;Hung, Mien-Chie
core  

Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction

Remodeled mitochondria are characteristic of pluripotent stem cells. However, a role for mitochondrial movement and distribution in pluripotency remains unknown.
Chen, Yongqiang, Liu, Zihuang, Ding, Yingzhe, Xiang, Ge, Li, Wei, Yuan, Zebin, Yang, Liang, Bao, Feixiang, Lin, Dongtong, Qin, Haihao, Yuan, Hao, Li, Linpeng, Wu, Yi, Liu, Xingguo, Huang, Yile, Long, Qi, Liu, Yang, Zhou, Shihe, Wang, Junwei, Dong, Shanshan, Ying, Zhongfu, Zheng, Zhihong, Chen, Keshi, Xie, Wei, Qin, Dajiang   +24 more
core   +1 more source

Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds

Tumor Biology, 2017
In cancer biology, the architectural concept “form follows function” is reflected by cell morphology, migration, and epithelial–mesenchymal transition protein pattern. In vivo, features of epithelial–mesenchymal transition have been associated with tumor
Kathrin Enderle-Ammour, Moritz Bader, Theresa Dorothee Ahrens, Kai Franke, Sylvia Timme, Agnes Csanadi, Jens Hoeppner, Birte Kulemann, Jochen Maurer, Philip Reiss, Oliver Schilling, Tobias Keck, Thomas Brabletz, Elmar Stickeler, Martin Werner, Ulrich Friedrich Wellner, Peter Bronsert   +16 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

IDEA 1997 Transition Issues: The IEP for Transition-Aged Students (NCSET Parent Brief)

, 2002
A brief explaining the requirements for transition under IDEA, the composition and functioning of the Individual Education Program (IEP) Transition Team, and special factors for the IEP Team to consider.
National Center on Secondary Education and Transition
core  

Stem Cell States, Fates, and the Rules of Attraction

, 2009
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different ...
Andrews, Peter W., Peterson, Carsten, Enver, Tariq, Pera, Martin, Peterson, Carsten,   +4 more
core   +1 more source

Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis

Advanced Science
A cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT,
Dongkwan Shin, Jeong‐Ryeol Gong, Seoyoon D. Jeong, Youngwon Cho, Hwang‐Phill Kim, Tae‐You Kim, Kwang‐Hyun Cho   +6 more
doaj   +1 more source