Results 111 to 120 of about 9,650,343 (306)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

, 2019
International audienceStromal cell populations that maintain hematopoietic stem and progenitor cells (HSPCs) are generally characterized in steady-state conditions.
Scadden, David, Scadden, Elizabeth, Rhee, Catherine, Kfoury, Youmna, Karabacak, Nezihi Murat, Brouse, Thomas, Baryawno, Ninib, Courties, Gabriel, Nahrendorf, Matthias, Lee, Dongjun, Severe, Nicolas, Gustafsson, Karin, Toner, Mehmet, Kokkaliaris, Konstantinos, Garcia-Robledo, Juan Esteban, Kfoury, Y, Courties, G, Lee, D, Gustafsson, K, Baryawno, N,, Scadden, EW, Rhee, C, Severe, N, Karabacak, NM, Kokkaliaris, KD   +24 more
core   +1 more source

Comprehensive transcriptomic and functional characterization of protoplast regeneration in Angelica gigas Nakai

BMC Plant Biology
Background Protoplasts that are isolated from various plant sources, including leaf mesophyll tissue, callus, will continue to have the ability to take part in cell wall regeneration, division, and expression of totipotency.
Han-Sol Lee, Jong-Eun Han, Donghwan Shim, Bae Young Choi, Hyunwoo Cho, Hosakatte Niranjana Murthy, So-Young Park   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Endothelial to mesenchymal cell transition in diabetic retinopathy: targets and therapeutics. [PDF]

Front Ophthalmol (Lausanne), 2023
Nijim W, Moustafa M, Humble J, Al-Shabrawey M.   +3 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Screening single-cell trajectories via continuity assessments for cell transition potential. [PDF]

Brief Bioinform, 2023
Zheng Z, Chang L, Li Y, Liu K, Mu J, Zhang S, Li J, Wu Y, Zou L, Ni Q, Wan Y.   +10 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Sensors of Succinate : Neural Stem Cell Grafts Fight Neuroinflammation

, 2018
In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory ...
Olle Lindvall, Kokaia, Zaal, Zaal Kokaia, Lindvall, Olle, Kokaia, Zaal,, Lindvall, Olle,, Lund University.   +6 more
core   +1 more source