Results 101 to 110 of about 28,363,573 (344)

Phenotypic variation of transcriptomic cell types in mouse motor cortex

Nature, 2020
Cortical neurons exhibit extreme diversity in gene expression as well as in morphological and electrophysiological properties1,2. Most existing neural taxonomies are based on either transcriptomic3,4 or morpho-electric5,6 criteria, as it has been ...
F. Scala, D. Kobak, Matteo Bernabucci, Yves Bernaerts, C. Cadwell, J. Castro, L. Hartmanis, Xiaolong Jiang, S. Laturnus, Elanine Miranda, Shalaka Mulherkar, Z. H. Tan, Z. Yao, Hongkui Zeng, R. Sandberg, Philipp Berens, A. Tolias   +16 more
semanticscholar   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

DeepIMAGER: Deeply Analyzing Gene Regulatory Networks from scRNA-seq Data

Biomolecules
Understanding the dynamics of gene regulatory networks (GRNs) across diverse cell types poses a challenge yet holds immense value in unraveling the molecular mechanisms governing cellular processes.
Xiguo Zhou, Jingyi Pan, Liang Chen, Shaoqiang Zhang, Yong Chen   +4 more
doaj   +1 more source

Monitoring the Right Collection: The Central Cholinergic Neurons as an Instructive Example

Frontiers in Neural Circuits, 2017
Some neurons are more equal than others: neuroscience relies heavily on the notion that there is a division of labor among different subtypes of brain cells.
Balázs Hangya, Katalin Sviatkó, Katalin Sviatkó   +2 more
doaj   +1 more source

Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map

bioRxiv, 2019
How closely human organoids recapitulate cell-type diversity and cell-type maturation of their target organs is not well understood. We developed human retinal organoids with multiple nuclear and synaptic layers.
C. Cowan, M. Renner, Brigitte Gross-Scherf, D. Goldblum, Martin Munz, J. Krol, T. Szikra, Panagiotis K. Papasaikas, Rachel Cuttat, Annick Waldt, Roland Diggelmann, Claudia P. Patino-Alvarez, N. Gerber-Hollbach, S. Schuierer, Yanyan Hou, Aldin Srdanovic, Márton Balogh, R. Panero, P. Hasler, Á. Kusnyerik, A. Szabo, Michael B. Stadler, S. Orgül, Andreas Hierlemann, H. Scholl, G. Roma, Florian Nigsch, B. Roska   +27 more
semanticscholar   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

An estimate of extracellular vesicle secretion rates of human blood cells

Journal of Extracellular Biology, 2022
Extracellular vesicles (EVs) have been implicated in the intercellular transfer of RNA and proteins through cellular secretion into the extracellular space.
Martin Auber, Per Svenningsen
doaj   +1 more source

Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

bioRxiv, 2017
Immune cells infiltrating tumors can have important impact on tumor progression and response to therapy. We present an efficient algorithm to simultaneously estimate the fraction of cancer and immune cell types from bulk tumor gene expression data.
Julien Racle, Kaat de Jonge, Petra Baumgaertner, D. Speiser, D. Gfeller   +4 more
semanticscholar   +1 more source

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Insights Into the Etiology of Parkinson’s Disease

Nature Genetics, 2020
Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active.
J. Bryois, N. Skene, T. Hansen, L. Kogelman, Hunna J. Watson, Leo Brueggeman, G. Breen, C. Bulik, E. Arenas, J. Hjerling-Leffler, P. Sullivan   +10 more
semanticscholar   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source