Results 111 to 120 of about 28,363,573 (344)

Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus

eLife, 2020
Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron ...
Tenzin Ngodup, Gabriel E Romero, Laurence O Trussell   +2 more
doaj   +1 more source

Reconstruction of 1,000 projection neurons reveals new cell types and organization of long-range connectivity in the mouse brain

bioRxiv, 2019
Neuronal cell types are the nodes of neural circuits that determine the flow of information within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides an essential descriptor of cell type and reveals how individual neurons ...
Johan Winnubst, Erhan Bas, Tiago A. Ferreira, Zhuhao Wu, M. Economo, Patrick Edson, B. J. Arthur, Christopher Bruns, Konrad Rokicki, David M. Schauder, D. J. Olbris, S. D. Murphy, David Ackerman, Cameron Arshadi, P. Baldwin, Regina Blake, A. Elsayed, Mashtura Hasan, D. Ramírez, Bruno Paiva dos Santos, Monet Weldon, A. Zafar, Joshua T. Dudmann, C. Gerfen, A. Hantman, Wyatt L. Korff, S. Sternson, N. Spruston, K. Svoboda, J. Chandrashekar   +29 more
semanticscholar   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

INTER-INDIVIDUAL VARIATION IN HUMAN CORTICAL CELL TYPE ABUNDANCE AND EXPRESSION

IBRO Neuroscience Reports, 2023
Nelson Johansen, Saroja Somasundaram, Kyle Travaglini, Anna Marie Yanny, Maya Shumyatcher, Tamara Casper, Charles Cobbs, Nick Dee, Richard Ellenbogen, Manuel Ferreira, Jeff Goldy, Junitta Guzman, Ryder Gwinn, Daniel Hirschstein, Nikolas Jorstad, C. Dirk Keene, Andrew Ko, Boaz Levi, Jeffrey Ojemann, Thanh Pham, Nadiya Shapovalova, Daniel Silbergeld, Josef Sulc, Amy Torkelson, Herman Tung, Kimberly Smith, Ed Lein, Trygve Bakken, Rebecca Hodge, Jeremy Miller   +29 more
doaj   +1 more source

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Neuron, 2018
(microglia-like cells). APOE4 neurons exhibited increased synapse number and elevated A b 42 secretion relative to isogenic APOE3 cells while APOE4 astrocytes displayed impaired A b uptake and cholesterol accumulation. Notably, APOE4 microglia-like cells
Yuan-Ta Lin, Jinsoo Seo, Fan Gao, Heather M. Feldman, Hsin-Lan Wen, Jay Penney, Hugh P Cam, Elizabeta Gjoneska, W. Raja, Jemmie Cheng, Richard Rueda, Oleg Kritskiy, Fatema Abdurrob, Zhuyu Peng, Blerta Milo, Chung Jong Yu, Sara Elmsaouri, Dilip Dey, Tak Ko, B. Yankner, L. Tsai   +20 more
semanticscholar   +1 more source

Jointly defining cell types from multiple single-cell datasets using LIGER

Nature Protocols, 2020
High-throughput single-cell sequencing technologies hold tremendous potential for defining cell types in an unbiased fashion using gene expression and epigenomic state.
Jialin Liu, Chao Gao, Joshua S. Sodicoff, Velina Kozareva, Evan Z. Macosko, Joshua D. Welch   +5 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

WHOLE BRAIN SINGLE NUCLEUS TRANSCRIPTOMICS IN HUMAN: WHAT WE KNOW SO FAR

IBRO Neuroscience Reports, 2023
Kimberly Siletti, Rebecca Hodge, Alejandro Mossi Albiach, Ka Wai Lee, Song-Lin Ding, Lijuan Hu, Peter Lönnerberg, Trygve Bakken, Tamara Casper, Michael Clark, Nick Dee, Jessica Gloe, C. Dirk Keene, Julie Nyhus, Herman Tung, Anna Marie Yanny, Ernest Arenas, Ed Lein, Sten Linnarsson   +18 more
doaj   +1 more source

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses [PDF]

, 2001
Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling.
Berridge, Michael J., Bootman, Martin D., De Smedt, Humbert, de Smet, Patrick, Holmes, Andrew, Lipp, Peter, Missiaen, Ludwig, Parys, Jan B., Thomas, David, Thuring, Jan, Tovey, Stephen C., Young, Kenneth W.   +11 more
core  

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan.

Cell Metabolism, 2020
The accumulation of senescent cells can drive many age-associated phenotypes and pathologies. Consequently, it has been proposed that removing senescent cells might extend lifespan.
Laurent Grosse, N. Wagner, A. Emelyanov, Clément Molina, S. Lacas‐Gervais, K. Wagner, D. Bulavin   +6 more
semanticscholar   +1 more source