Results 61 to 70 of about 1,019,407 (314)

Green Bioprinting with Layer-by-Layer Photo-Crosslinking: A Designed Experimental Investigation on Shape Fidelity and Cell Viability of Printed Constructs

Journal of Manufacturing and Materials Processing, 2022
Process variables of bioprinting (including extrusion pressure, nozzle size, and bioink composition) can affect the shape fidelity and cell viability of printed constructs.
Ketan Thakare, Laura Jerpseth, Zhijian Pei, Hongmin Qin   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines. [PDF]

, 2015
Recent clinical trials investigating receptor tyrosine kinase (RTK) inhibitors showed a limited clinical response in medulloblastoma. The present study investigated the role of micro-environmental growth factors expressed in the brain, such as HGF and ...
Meeuwsen-de Boer, Tiny, Tiny Meeuwsen-de Boer, Plasschaert, Sabine L. A., Walderik W. Zomerman (709795), Tiny Meeuwsen-de Boer (817787), Lourens, Harm-Jan, Lourens , Harm-Jan, Walderik W Zomerman, den Dunnen, Wilfred F. A.; id_orcid, Diks, Sander H., Sander H. Diks (33652), Harm-Jan Lourens (817786), Wilfred F A den Dunnen, Sander H Diks, Eveline S J M de Bont, Harm-Jan Lourens, Eveline S. J. M. de Bont (87571), Hoving, Eelco W., den Dunnen, Wilfred F. A., Wilfred F. A. den Dunnen (697910), Sabine L A Plasschaert, Eelco W. Hoving (709797), Zomerman, Waldrik W, Sabine L. A. Plasschaert (817785), de Bont, Eveline S. J. M., Eelco W Hoving   +25 more
core   +1 more source

Investigation of Sterol structures and biological activities in Cochineal and Hibiscus sabdariffa extracts

International Journal of Secondary Metabolite
In the future, it is necessary to discover natural resources with no or less toxicity and side effects instead of synthetic drugs. Therefore, it is crucial to recognize, isolate, measure, and reveal the biological activities of substances in the ...
Mehmet Çadır, Nilgün Kuşçulu, Dilek Bahar   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Two homologous Agr-like quorum-sensing systems cooperatively control adherence, cell morphology, and cell viability properties in Lactobacillus plantarum WCFS1

, 2008
A two-component regulatory system of Lactobacillus plantarum, encoded by genes designated lamK and lamR (hpk10 and rrp10), was studied. The lamK and lamR genes encode proteins which are highly homologous to the quorum-sensing histidine kinase LamC and ...
Vos, W.M., de, Kleerebezem, M., Kunuki, Ryoko, Ingham, C.J., Sturme, Mark, Nakayama, J., Vaughan, Elaine, Kunuki, R., Nakayama, Jiro, Sturme, M.H.J., Fujii, Toshio, Kleerebezem, Michiel, Molenaar, D., Fujii, T., Vaughan, E.E., Ingham, Colin, Beerthuyzen, Marke, Molenaar, Douwe, de Vos, Willem, Molenaar, Douwe; id_orcid, de Vos, W.M., Beerthuyzen, M.M.   +21 more
core   +1 more source

Critical location of cell viability loss during the cell injection process in hepatocyte transplantation using a rectangular microchannel model

Journal of Biomechanical Science and Engineering, 2017
A sufficient number of functional live hepatocytes delivered to a recipient is necessary for cell therapy. Preventing cell viability loss during the cell injection process is important to improve the clinical outcomes of hepatocyte transplantation.
Sandi SUFIANDI, Hiromichi OBARA, Huai-Che HSU, Shin ENOSAWA, Naoto MATSUNO, Hiroshi MIZUNUMA   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity

Molecules, 2020
Albendazole is a benzimidazole derivative with documented antitumor activity and low toxicity to healthy cells. The major disadvantage in terms of clinical use is its low aqueous solubility which limits its bioavailability.
Roxana Racoviceanu, Cristina Trandafirescu, Mirela Voicu, Roxana Ghiulai, Florin Borcan, Cristina Dehelean, Claudia Watz, Zoltán Aigner, Rita Ambrus, Dorina Elena Coricovac, Denisa Cîrcioban, Alexandra Mioc, Camelia Alexandrina Szuhanek, Codruţa Şoica   +13 more
doaj   +1 more source