Results 71 to 80 of about 5,277,948 (253)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Transcriptional activity around bacterial cell death reveals molecular biomarkers for cell viability [PDF]

, 2008
Background In bacteriology, the ability to grow in selective media and to form colonies on nutrient agar plates is routinely used as a retrospective criterion for the detection of living bacteria.
Schuren Frank H, Keijser, B.J., Caspers Martien PM, Kort, Remco; id_orcid, Keijser, Bart J, Montijn, R., Montijn, Roy C, Kort, Remco, Keijser Bart J, Kort Remco, Caspers, M.P.M., Caspers, Martien P M, Kort, R., Schuren, F.H., Schuren, Frank H J, Montijn Roy   +15 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Biotechnological Potential of Isolated Bacteria from Post-Consumer LED Lamps for Solubilization of Critical Metals [PDF]

Materials Research
This study evaluates the biotechnological potential of isolated microorganisms for the solubilization of critical and valuable metals in LED lamp waste through a biometallurgical process, called bioleaching or biomineration, which occurs with the ...
Isabela Natália da Silva Ferreira, Emanuele Caroline Araujo Eschtiler, Adriana Ferreira Souza, Débora Machado de Souza, Rosileide Fontenele da Silva Andrade, Galba Campos-Takaki, Victor Hugo Valiati, Carlos Alberto Mendes Moraes, Feliciane Andrade Brehm   +8 more
doaj   +1 more source

The Effect of Metamizole on Viability and Oxidative Stress in the C6 Rat Glioma Cell Line

Acta Veterinaria
Metamizole is a pyrazolone-derived drug with analgesic, antipyretic and spasmolytic activity. The available literature data on metamizole effects on tumor cell lines is limited.
Zekovic Janko, Stanojevic Zeljka, Tasic Jelena, Radovic Filip, Blagojevic Sanja, Isakovic Aleksandra, Novakovic Sasenka Vidicevic   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluation of Antibiofilm and Cytotoxic Activity of Microalgae Isolated from Different Sites of betwata- Erbil/Iraq

مجلة بغداد للعلوم
This in vivo study is aimed to assess the antibiofilm and cytotoxic potential of selected microalgae isolates. Different concentration of microalgal isolates used for each of antibiofilm and cytotoxic studies.
Sewgil Saaduldeen Anwer, Ayad Kareem Ali, Nur Bozbeyoglu Kart, Dogukan Mutlu, Refika Ceyda Beram, Volkan Kuzucu, Sevki Arslan, Nazime Mercan Dogan   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Agriculture Viability Grants Program : [application] 2019.

, 2019
Annual; "Farm Viability Grant, Farm Transition Grant."; Funding for the State of Connecticut agriculture viability grants was established in 2005 through Public Act 05-228, an Act Concerning Farm Land Preservation, Land Protection, Affordable Housing and
Agriculture Viability Grants Program (Conn.)
core   +1 more source