Results 71 to 80 of about 1,019,407 (314)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2010 In this study, we compared the potencies of diosgenin, a plant-derived sapogenin structurally similar to estrogen and progesterone, on vascular smooth muscle functions ranging from contraction and migration to apoptosis.
Cornelis van Breemen +17 more
core +1 more source
A linear shear model of cell viability loss during hepatocyte transplantation
Journal of Biomechanical Science and Engineering, 2017 Improving the process of cell injection during hepatocyte transplantation requires an understanding of the causal relationships that shear, direct contact cells with a solid surface, and cell deformation have on cell viability loss.
Sandi SUFIANDI +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Comparação in vitro da efetividade de vários meios de conservação na manutenção da viabilidade de fibroblastos do ligamento periodontal de dentes humanos [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em OdontologiaOs objetivos deste estudo foram: estabelecer uma linhagem de fibroblastos oriundos de ligamento periodontal de dentes ...
Kremer, Beatriz Dulcineia Mendes de Souza
core
Quantitative ratiometric Ca2+ imaging to assess cell viability
, 2017 Viability of cells is strongly related to their Ca2+ homeostasis. Ca2+ signal fluctuations can be on a slow time scale, e.g., in non-excitable cells, but also in the range of tens of milliseconds for excitable cells, such as nerve and muscle.
Oliver Friedrich +3 more
core +1 more source
Cell population, viability, and some key immunomodulatory molecules in different milk somatic cell samples in dairy cows [PDF]
, 2009 Immune cells in the milk are most important in combating pathogens that invade the mammary gland. This study investigated the immune competence and viability of somatic milk cells that are already resident in milk and udders free of infection. Cells were
Wellnitz, O. +5 more
core +1 more source
یافتههای نوین در علوم زیستی, 2022 Lung carcinoma is the second most common type of cancer. Inefficiency of the current treatments and the undesirable side effects of chemotherapy drugs made the know-how of the treatment important.
Mona Motaharinia, Mohammad Nabiuni
doaj
A multiparametric assay to compare the cytotoxicity of different storage media for avulsed teeth
Brazilian Journal of Oral Sciences, 2015 Aim: To evaluate the cytotoxicity of several storage media (coconut water, whole milk, isotonic solution, Hank´s Balanced Salt Solution and tap water) using a multiparametric cytotoxicity analysis employing 3T3 cells. Methods: Plates containing confluent
Emmanuel João Nogueira Leal Silva +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source