Special Issue “The Fungal Cell Wall Integrity Pathway” [PDF]
Journal of Fungi, 2023 Adaptation to external changes is necessary for all cell types to survive and thrive in diverse environments [...]
Humberto Martín, María Molina
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Cell Wall Integrity Pathway Involved in Morphogenesis, Virulence and Antifungal Susceptibility in Cryptococcus neoformans [PDF]
Journal of Fungi, 2021 Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during infection as well as in different biological functions such as cell morphology, cell ...
Haroldo Cesar de Oliveira +4 more
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Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway [PDF]
mSphere, 2020 The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance.
Siddharth K. Tripathi +12 more
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Molecular Plant-Microbe Interactions, 2023 The fungal cell wall is the first layer exposed to the external environment. The cell wall has key roles in regulating cell functions, such as cellular stability, permeability, and protection against stress.
Kailun Lu +5 more
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Integration of human ERKs and DUSPs into the yeast cell wall integrity pathway [PDF]
Scientific ReportsThe Saccharomyces cerevisiae Cell Wall Integrity (CWI) pathway responds to cell wall stress and is composed of MAP3K Bck1, MAP2Ks Mkk1 and Mkk2 and MAPK Slt2. Although human ERK5 has been considered the functional orthologue of Slt2, our results indicate
Beatriz Lavilla-García +3 more
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The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression
Journal of Fungi, 2021 Cell-signaling pathways are essential for cells to respond and adapt to changes in their environmental conditions. The cell-wall integrity (CWI) pathway of Saccharomyces cerevisiae is activated by environmental stresses, compounds, and morphogenetic ...
Inma Quilis +2 more
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KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata. [PDF]
PLoS ONE, 2016 The maintenance of cell wall integrity in fungi is required for normal cell growth, division, hyphae formation, and antifungal tolerance. We observed that endoplasmic reticulum stress regulated cell wall integrity in Candida glabrata, which possesses ...
Yutaka Tanaka +7 more
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iScience, 2021 Summary: The cell wall is an essential dynamic structure for shielding fungus from environmental stress, and its synthesizing and remodeling are regulated by the cell wall integrity (CWI) pathway.
Can Tan +7 more
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A posttranscriptional pathway regulates cell wall mRNA expression in budding yeast
Cell Reports, 2023 Summary: The fungal cell wall provides protection and structure and is an important target for antifungal compounds. A mitogen-activated protein (MAP) kinase cascade termed the cell wall integrity (CWI) pathway regulates transcriptional responses to cell
Stefan Bresson +2 more
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WSC-1 and HAM-7 are MAK-1 MAP kinase pathway sensors required for cell wall integrity and hyphal fusion in Neurospora crassa. [PDF]
PLoS ONE, 2012 A large number of cell wall proteins are encoded in the Neurospora crassa genome. Strains carrying gene deletions of 65 predicted cell wall proteins were characterized.
Abhiram Maddi +4 more
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