Results 31 to 40 of about 103,075 (235)

Genetic dissection of the signaling pathway required for the cell wall integrity checkpoint [PDF]

Journal of Cell Science, 2018
ABSTRACT The cell wall integrity checkpoint monitors synthesis of cell wall materials during the Saccharomyces cerevisiae cell cycle. Upon perturbation of cell wall synthesis, the cell wall integrity checkpoint is activated, downregulating Clb2 transcription.
Yuko Sukegawa, Takahiro Negishi, Yo Kikuchi, Keiko Ishii, Miyuki Imanari, Farzan Ghanegolmohammadi, Satoru Nogami, Yoshikazu Ohya   +7 more
openaire   +2 more sources

A seven-membered cell wall related transglycosylase gene family in Aspergillus niger is relevant for cell wall integrity in cell wall mutants with reduced α-glucan or galactomannan

The Cell Surface, 2020
Chitin is an important fungal cell wall component that is cross-linked to β-glucan for structural integrity. Acquisition of chitin to glucan cross-links has previously been shown to be performed by transglycosylation enzymes in Saccharomyces cerevisiae ...
Tim M. van Leeuwe, Jasper Wattjes, Anna Niehues, Gabriel Forn-Cuní, Nicholas Geoffrion, Hugo Mélida, Mark Arentshorst, Antonio Molina, Adrian Tsang, Annemarie H. Meijer, Bruno M. Moerschbacher, Peter J. Punt, Arthur F.J. Ram   +12 more
doaj   +1 more source

Analysis of the cell wall integrity pathway of Ashbya gossypii

Microbiological Research, 2013
Fungal cells are exposed to rapidly changing environmental conditions, in particular with regard to the osmotic potential. This requires constant remodeling of the cell wall and, therefore, the cell wall integrity (CWI) MAP-kinase pathway plays a major role in shaping the fungal cell wall to protect from adverse external stresses.
Lengeler, Klaus B., Wasserstrom, Lisa, Walther, Andrea, Wendland, Jürgen   +3 more
openaire   +2 more sources

Crosstalk between the calcineurin and cell wall integrity pathways prevents chitin overexpression in Candida albicans [PDF]

Journal of Cell Science, 2021
ABSTRACT Echinocandins such as caspofungin are frontline antifungal drugs that compromise β-1,3 glucan synthesis in the cell wall. Recent reports have shown that fungal cells can resist killing by caspofungin by upregulation of chitin synthesis, thereby sustaining cell wall integrity (CWI).
Alessandra da Silva Dantas, Filomena Nogueira, Keunsook K. Lee, Louise A. Walker, Matt Edmondson, Alexandra C. Brand, Megan D. Lenardon, Neil A. R. Gow   +7 more
openaire   +3 more sources

A Mutant of the Bck1 Homolog from Cryphonectria parasitica Resulted in Sectorization with an Impaired Pathogenicity

Molecular Plant-Microbe Interactions, 2016
CpBck1, an ortholog of the cell-wall integrity mitogen-activated protein kinase kinase kinase of Saccharomyces cerevisiae, was cloned and characterized from the chestnut blight fungus Cryphonectria parasitica.
Jung-Mi Kim, Joong-Gi Lee, Suk-Hyun Yun, Kum-Kang So, Yo-Han Ko, Young Ho Kim, Seung-Moon Park, Dae-Hyuk Kim   +7 more
doaj   +1 more source

The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast

Journal of Fungi, 2017
Fungi are surrounded by an essential structure, the cell wall, which not only confers cell shape but also protects cells from environmental stress.
Ana Belén Sanz, Raúl García, José M. Rodríguez-Peña, Javier Arroyo   +3 more
doaj   +1 more source

Differential Requirement for the Cell Wall Integrity Sensor Wsc1p in Diploids Versus Haploids

Journal of Fungi, 2021
The primary role of the Cell Wall Integrity Pathway (CWI) in Saccharomyces cerevisiae is monitoring the state of the cell wall in response to general life cycle stresses (growth and mating) and imposed stresses (temperature changes and chemicals). Of the
Allison E. Hall, Miriam Lisci, Mark D. Rose   +2 more
doaj   +1 more source

Ssd1 and the cell wall integrity pathway promote entry, maintenance, and recovery from quiescence in budding yeast. [PDF]

Mol Biol Cell, 2019
Wild Saccharomyces cerevisiae strains are typically diploid. When faced with glucose and nitrogen limitation they can undergo meiosis and sporulate. Diploids can also enter a protective, nondividing cellular state or quiescence. The ability to enter quiescence is highly reproducible but shows broad natural variation.
Miles S, Li LH, Melville Z, Breeden LL.
europepmc   +3 more sources

To preserve or to destroy, that is the question: the role of the cell wall integrity pathway in pollen tube growth [PDF]

Current Opinion in Plant Biology, 2019
In plants, cell-shape is defined by the cell wall, a complex network of polymers located outside the plasma membrane. During cell growth, cell wall properties have to be adjusted, assuring cell expansion without compromising cell integrity. Plasma membrane-located receptors sense cell wall properties, transducing extracellular signals into ...
Vogler, Hannes, Santos-Fernandez, Gorka, Mecchia, Martin A, Grossniklaus, Ueli   +3 more
openaire   +4 more sources

Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity

Journal of Fungi, 2022
The cell wall integrity (CWI) MAPK pathway of budding yeast Saccharomyces cerevisiae is specialized in responding to cell wall damage, but ongoing research shows that it participates in many other stressful conditions, suggesting that it has functional ...
Gema González-Rubio, Lucía Sastre-Vergara, María Molina, Humberto Martín, Teresa Fernández-Acero   +4 more
doaj   +1 more source