The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression
Journal of Fungi, 2021 Cell-signaling pathways are essential for cells to respond and adapt to changes in their environmental conditions. The cell-wall integrity (CWI) pathway of Saccharomyces cerevisiae is activated by environmental stresses, compounds, and morphogenetic ...
Inma Quilis +2 more
doaj +1 more source
KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata. [PDF]
PLoS ONE, 2016 The maintenance of cell wall integrity in fungi is required for normal cell growth, division, hyphae formation, and antifungal tolerance. We observed that endoplasmic reticulum stress regulated cell wall integrity in Candida glabrata, which possesses ...
Yutaka Tanaka +7 more
doaj +1 more source
Cell Wall Integrity MAPK Pathway Is Essential for Lipid Homeostasis [PDF]
Journal of Biological Chemistry, 2008 The highly conserved yeast cell wall integrity mitogen-activated protein kinase pathway regulates cellular responses to cell wall and membrane stress. We report that this pathway is activated and essential for viability under growth conditions that alter both the abundance and pattern of synthesis and turnover of membrane phospholipids, particularly ...
Lilia R, Nunez +7 more
openaire +2 more sources
iScience, 2021 Summary: The cell wall is an essential dynamic structure for shielding fungus from environmental stress, and its synthesizing and remodeling are regulated by the cell wall integrity (CWI) pathway.
Can Tan +7 more
doaj +1 more source
A posttranscriptional pathway regulates cell wall mRNA expression in budding yeast
Cell Reports, 2023 Summary: The fungal cell wall provides protection and structure and is an important target for antifungal compounds. A mitogen-activated protein (MAP) kinase cascade termed the cell wall integrity (CWI) pathway regulates transcriptional responses to cell
Stefan Bresson +2 more
doaj +1 more source
WSC-1 and HAM-7 are MAK-1 MAP kinase pathway sensors required for cell wall integrity and hyphal fusion in Neurospora crassa. [PDF]
PLoS ONE, 2012 A large number of cell wall proteins are encoded in the Neurospora crassa genome. Strains carrying gene deletions of 65 predicted cell wall proteins were characterized.
Abhiram Maddi +4 more
doaj +1 more source
Roles of High Osmolarity Glycerol and Cell Wall Integrity Pathways in Cadmium Toxicity in Saccharomyces cerevisiae [PDF]
International Journal of Molecular Sciences, 2021 Cadmium is a carcinogen that can induce ER stress, DNA damage, oxidative stress and cell death. The yeast mitogen-activated protein kinase (MAPK) signalling pathways paly crucial roles in response to various stresses. Here, we demonstrate that the unfolded protein response (UPR) pathway, the high osmolarity glycerol (HOG) pathway and the cell wall ...
Yunying Zhao +4 more
openaire +2 more sources
The Cell Surface, 2021 Understanding the molecular mechanisms governing antifungal resistance is crucial for identifying new cellular targets for developing new antifungal therapeutics.
Guisheng Zeng +5 more
doaj +1 more source
The Role of the Cell Integrity Pathway in Septum Assembly in Yeast
Journal of Fungi, 2021 Cytokinesis divides a mother cell into two daughter cells at the end of each cell cycle and proceeds via the assembly and constriction of a contractile actomyosin ring (CAR).
Cesar Roncero +4 more
doaj +1 more source
Author Correction: Signalling through the yeast MAPK Cell Wall Integrity pathway controls P-body assembly upon cell wall stress. [PDF]
Sci Rep, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
García R +6 more
europepmc +4 more sources