Special Issue “The Fungal Cell Wall Integrity Pathway” [PDF]
Journal of Fungi, 2023 Adaptation to external changes is necessary for all cell types to survive and thrive in diverse environments [...]
Humberto Martín, María Molina
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Molecular Plant-Microbe Interactions, 2023 The fungal cell wall is the first layer exposed to the external environment. The cell wall has key roles in regulating cell functions, such as cellular stability, permeability, and protection against stress.
Kailun Lu +5 more
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Cell Wall Integrity Pathway Involved in Morphogenesis, Virulence and Antifungal Susceptibility in Cryptococcus neoformans [PDF]
Journal of Fungi, 2021 Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during infection as well as in different biological functions such as cell morphology, cell ...
Haroldo Cesar de Oliveira +4 more
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Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway [PDF]
mSphere, 2020 The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance.
Siddharth K. Tripathi +12 more
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Integration of human ERKs and DUSPs into the yeast cell wall integrity pathway [PDF]
Scientific ReportsThe Saccharomyces cerevisiae Cell Wall Integrity (CWI) pathway responds to cell wall stress and is composed of MAP3K Bck1, MAP2Ks Mkk1 and Mkk2 and MAPK Slt2. Although human ERK5 has been considered the functional orthologue of Slt2, our results indicate
Beatriz Lavilla-García +3 more
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The Cell Wall Integrity Signaling Pathway and Its Involvement in Secondary Metabolite Production [PDF]
Journal of Fungi, 2017 The fungal cell wall is the external and first layer that fungi use to interact with the environment. Every stress signal, before being translated into an appropriate stress response, needs to overtake this layer.
Vito Valiante
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Involvement of the Cell Wall Integrity Pathway of Saccharomyces cerevisiae in Protection against Cadmium and Arsenate Stresses. [PDF]
Appl Environ Microbiol, 2020 Environmental pollution by metal/metalloids such as cadmium and arsenic has become a serious problem in many countries, especially in developing countries. This study shows that in the yeast S. cerevisiae , the CWI pathway plays a protective role against cadmium and arsenate through the upregulation of genes ...
Techo T +2 more
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Activation of the cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling through blocking eisosome disassembly in Saccharomyces cerevisiae [PDF]
Communications BiologyThe target of rapamycin complex 2 (TORC2) signaling is associated with plasma membrane (PM) integrity. In Saccharomyces cerevisiae, TORC2-Ypk1/2 signaling controls sphingolipid biosynthesis, and Ypk1/2 phosphorylation by TORC2 under PM stress conditions ...
Wataru Nomura, Yoshiharu Inoue
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Journal of Fungi, 2021 Azoles are one of the most widely used drugs to treat fungal infections. To further understand the fungal response to azoles, we analyzed the MAPK circuitry of the model yeast Saccharomyces cerevisiae that operates under treatment with these antifungals.
Ángela Sellers-Moya +3 more
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Nitric oxide enhances ethanol stress tolerance in Wickerhamomyces anomalus through modulating cell membrane and cell wall homeostasis [PDF]
BMC MicrobiologyBackground Wickerhamomyces anomalus has garnered significant interest for its remarkable ability to shape wine flavor profiles. However, during fermentation, yeast cells are inevitably exposed to ethanol stress.
Xiaozhu Liu +4 more
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