Results 181 to 190 of about 3,724,194 (363)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Heterologous ORFV-Ad26 vaccination broadens antibody breadth and amplifies cellular immunity against SARS-CoV-2 spike. [PDF]

Front Immunol
Reguzova A, Haug V, Müller M, Fandrich M, Dulovic A, Amann R.   +5 more
europepmc   +1 more source

Persistent Loss of Hepatitis B Virus Markers in Serum without Cellular Immunity by Combination of Peginterferon and Entecavir Therapy in Humanized Mice [PDF]

, 2017
Takuro Uchida, Michio Imamura, C. Nelson Hayes, Nobuhiko Hiraga, Hiromi Kan, Masataka Tsuge, Hiromi Abe‐Chayama, Yizhou Zhang, Grace Naswa Makokha, Hiroshi Aikata, Daiki Miki, Hidenori Ochi, Yuji Ishida, Chise Tateno, Kazuaki Chayama   +14 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Suppression of cellular immunity by cord blood‐derived unrestricted somatic stem cells is cytokine‐dependent [PDF]

, 2008
Meike Winter, Xiao‐Nong Wang, Walter Däubener, Annette Eyking, Michelle Rae, Anne M. Dickinson, Peter Wernet, Gesine Kögler, Rüdiger V. Sorg   +8 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The catalytic A1 domains of cholera toxin and heat-labile enterotoxin are potent DNA adjuvants that evoke mixed Th1/Th17 cellular immune responses [PDF]

, 2015
Kenneth Bagley, Rong Xu, Ayuko Ota‐Setlik, Michael A. Egan, Jennifer A. Schwartz, Timothy Fouts   +5 more
openalex   +1 more source

Autophagy in tumour immunity and therapy

Nature Reviews. Cancer, 2021
Houjun Xia, D. Green, W. Zou
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity. [PDF]

BMC Med
Méndez C, Rodríguez-Guilarte L, Palacios PA, Gutierrez-Vera C, Román F, Moreno-Tapia D, Ríos M, Reyes A, Cancino FA, Otero FF, Zurita C, Rivera D, Cabrera A, Duarte LF, Urzúa M, Iturriaga C, Rojas Á, Perez CM, Redlich AS, Fasce RA, Fernández J, Mora J, Ramírez E, Domínguez A, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, Goldbatt D, Johnson M, CoronaVarCL study group, González-Aramundiz JV, Álvarez-Figueroa MJ, Abarca K, Carreño LJ, González PA, Kalergis AM, Peñaloza HF, Bueno SM.   +39 more
europepmc   +1 more source