Results 201 to 210 of about 2,153,248 (300)

Enhanced Th1 Cellular Immunity Induced by an RSV-F mRNA Vaccine Rationally Designed Using NLP Algorithms. [PDF]

Vaccines (Basel)
Xia ZW, Tang Q, Pan JJ, Liu J, Jia LX, Zhang GM, Xie MN, Zheng JH, Lv CS, Zhang L, Shi YH, He L, Luo M, Zhao JL.   +13 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The Effects of Past COVID-19 and Vaccination on Antibody Levels, Cellular Immunity, and Cytokine Production by Peripheral Blood Mononuclear Cells. [PDF]

Biomedicines
Desheva YA, Gupalova TV, Kudar PA, Leontieva GF, Kudryavtsev IV, Trulioff AS, Guzenkov DS, Matyushenko VA, Bormotova EA, Sokolovsky DD, Matveev GA, Nikolaev BP, Suvorov AN.   +12 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The Impact of Hemodialysis on Humoral and Cellular Immunity in Patients with Renal Failure. [PDF]

J Clin Med
Alhamawi RM, Shafea BY, Bakhsh HH, Fayraq LA, Aloufi ST, Alharbi TF, Alharbi AA, Alharbi AA, Alanize BF, Bakhsh AM, Rajih ES, Sandokji IA, Mahallawi WH.   +12 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Within host dynamics of HPV infection with cellular immunity and HPV-infected dormant cells reactivation. [PDF]

Infect Dis Model
Chapwanya M, Fouape AC, Tsanou B.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

T cell antigenic recognition sequencing (TAR-seq) enables precise characterization of vaccine-elicited cellular immunity ex vivo and <i>in vivo</i>. [PDF]

Front Immunol
Chaunzwa M, McElfresh GW, Morrow D, Boggy GJ, Kaza M, Benjamin S, Feltham S, Ojha S, Swarbrick GM, Rott KH, Gilbride RM, Labriola CS, Axthelm MK, Joag V, Kain D, Plessis ND, Walzl G, Lewinsohn DA, Lewinsohn DM, Hansen SG, Picker LJ, Bimber BN.   +21 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source