Results 211 to 220 of about 2,055,112 (303)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Recombinant Japanese Encephalitis Virus Envelope Antigen Presented on CoPoP Liposomes Elicits Cellular Immunity and Protects Mice From Lethal Challenge. [PDF]

Immune Netw
Kim SY, Jung IR, Park H, Choi JO, Kim SH, Pak J, Kim J, Choi C, Kwon SY, Jeong K, Kim N, Kim J, Nam KT, Jeong DG, Shim DH, Lee JM, Kang JM, Hwang SS, Lee JY.   +18 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Heterologous ORFV-Ad26 vaccination broadens antibody breadth and amplifies cellular immunity against SARS-CoV-2 spike. [PDF]

Front Immunol
Reguzova A, Haug V, Müller M, Fandrich M, Dulovic A, Amann R.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Mannose and phenylboronate ester functionalized mesoporous silica nanoparticles contained in chitosan microneedles for enhancing cellular immunity and antitumor efficacy. [PDF]

Theranostics
Chen N, He Y, Zhang Y, Cui Y, Lu H, Zhang J, Zhang H, Zhao Q, Mao Y, Gao Y, Wang S.   +10 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Longitudinal analysis of humoral and cellular immunity in SARS-CoV-2 exposed families. [PDF]

Sci Rep
Dulovic A, Rabsteyn A, Remppis J, Gentzcke IKE, Mueller J, Tuecks N, Becker M, Junker D, Kaiser PD, Traenkle B, Rothbauer U, Walz JS, Peter A, Hörber S, Ganzenmueller T, Iftner T, Stich M, Tönshoff B, Henneke P, Elling R, Debatin KM, Janda A, Schneiderhan-Marra N, Franz AR, Lang P, Renk H.   +25 more
europepmc   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity. [PDF]

BMC Med
Méndez C, Rodríguez-Guilarte L, Palacios PA, Gutierrez-Vera C, Román F, Moreno-Tapia D, Ríos M, Reyes A, Cancino FA, Otero FF, Zurita C, Rivera D, Cabrera A, Duarte LF, Urzúa M, Iturriaga C, Rojas Á, Perez CM, Redlich AS, Fasce RA, Fernández J, Mora J, Ramírez E, Domínguez A, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, Goldbatt D, Johnson M, CoronaVarCL study group, González-Aramundiz JV, Álvarez-Figueroa MJ, Abarca K, Carreño LJ, González PA, Kalergis AM, Peñaloza HF, Bueno SM.   +39 more
europepmc   +1 more source