Results 81 to 90 of about 777,473 (267)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Mask protein keeps NF-κB precursor inactive by inducing a closed conformation and isolating it in biomolecular condensates

Cell Reports
Summary: Nuclear factor κB (NF-κB) family transcription factors are critical for innate immune responses across a variety of organisms and are frequently dysregulated in diseases.
Kewei Zheng, Xiawei Huang, Xiaojiang Yang, Jiahui Wang, Minhuang Hu, Chengfang Wu, Bo Liu   +6 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Interference Management using Power Control for Device-to-Device Communication in Future Cellular Network

Journal of Telecommunications and Information Technology, 2018
There are many scenarios that have been proposed for fifth generation (5G) networks. Some of them, if implemented, will bring fundamental changes at the architectural and node level.
Toha Ardi Nugraha, Muhammad Putra Pamungkas, Anna Nur Nazilah Chamim   +2 more
doaj   +1 more source

Middleware for Positioning in Cellular Networks

, 2011
Peer ...
Martín Escalona, Israel, Barceló Arroyo, Francisco, Ciurana Adell, Marc   +2 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

SPATIAL STRUCTURE OF INTERNET-TRAFIC CONSUMPTION IN THE MTS NETWORK IN A LARGE CITY (BASED ON KRASNODAR DATA)

InterCarto. InterGIS, 2015
For the first time based on the developed technique the authors studied the spatial structure of consumption of the Internet traffic in the MTS network in the territory of a large city - Krasnodar.
A. V. Pogorelov, K. R. Golovan, M. V. Kuzyakina   +2 more
doaj   +1 more source