Results 21 to 30 of about 2,083,118 (320)

Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory [PDF]

, 2016
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ...
Albertini, Giulia, De Bundel, Dimitri, Leybaert, Luc, Smolders, Ilse J., Vinken, Mathieu, Walrave, Laura   +5 more
core   +16 more sources

Cellular Biophysics and Modeling: A Required Course in the Neuroscience Program at William and Mary

Biophysical Journal, 2019
Gregory D. Smith
openalex   +3 more sources

In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine

iScience, 2022
Summary: New evidence is emerging about the dynamics of interaction between circadian rhythms and brain waves, whose coordination occurs through the entrainment process.
Barbara Pavan, Anna Bianchi, Giada Botti
doaj   +1 more source

Heterogeneity of intrinsic plasticity in cerebellar Purkinje cells linked with cortical molecular zones

iScience, 2022
Summary: In the cerebellar cortex, heterogeneous populations of Purkinje cells (PCs), classified into zebrin (aldolase C)-positive (Z+) and -negative (Z-) types, are arranged into separate longitudinal zones.
Nguyen-Minh Viet, Tianzhuo Wang, Khoa Tran-Anh, Izumi Sugihara   +3 more
doaj   +1 more source

Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus

iScience, 2023
Summary: Dorsal and ventral hippocampus serve different functions in cognition and affective behavior, but the underpinnings of this diversity at the cellular and synaptic level are not well understood.
Marc Dahlmanns, Maria Jesus Valero-Aracama, Jana Katharina Dahlmanns, Fang Zheng, Christian Alzheimer   +4 more
doaj   +1 more source

Muscarinic acetylcholine receptor-dependent and NMDA receptor-dependent LTP and LTD share the common AMPAR trafficking pathway

iScience, 2023
Summary: The forebrain cholinergic system promotes higher brain function in part by signaling through the M1 muscarinic acetylcholine receptor (mAChR). Long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission in the
Tomonari Sumi, Kouji Harada
doaj   +1 more source

Differential recruitment of ventral pallidal e-types by behaviorally salient stimuli during Pavlovian conditioning

iScience, 2021
Summary: The ventral pallidum (VP) is interfacing striatopallidal and limbic circuits, conveying information about salience and valence crucial to adjusting behavior.
Panna Hegedüs, Julia Heckenast, Balázs Hangya   +2 more
doaj   +1 more source

Homunculus Models in Neuroscience, Immunology, and Quantum Biology: Insights into Cellular Signaling and Communication

International Journal of Innovative Science and Research Technology
Human nature is highly complex and considered as an open non-equilibrium stochastic system. The complexity of biological systems related to the nature of cells, diverse components including, spatio-temporal interactions, constant modification, nonlinearity, networking, stochasticity, emergence, feedback loops, dependencies, competitions, degeneracy ...
Mohammad Ebrahimi
openalex   +2 more sources

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

iScience, 2023
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy   +7 more
doaj   +1 more source