Results 21 to 30 of about 2,109,260 (296)

Differential recruitment of ventral pallidal e-types by behaviorally salient stimuli during Pavlovian conditioning

iScience, 2021
Summary: The ventral pallidum (VP) is interfacing striatopallidal and limbic circuits, conveying information about salience and valence crucial to adjusting behavior.
Panna Hegedüs, Julia Heckenast, Balázs Hangya   +2 more
doaj   +1 more source

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

iScience, 2023
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy   +7 more
doaj   +1 more source

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source

Remote cortical perturbation dynamically changes the network solutions to given tactile inputs in neocortical neurons

iScience, 2022
Summary: The neocortex has a globally encompassing network structure, which for each given input constrains the possible combinations of neuronal activations across it. Hence, its network contains solutions.
Leila Etemadi, Jonas M.D. Enander, Henrik Jörntell   +2 more
doaj   +1 more source

Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption

iScience, 2021
Summary: The paraventricular nucleus of the thalamus (PVT) controls goal-oriented behavior through its connections to the nucleus accumbens (NAc). We previously characterized Glut2aPVT neurons that are activated by hypoglycemia, and which increase ...
Sébastien Kessler, Gwenaël Labouèbe, Sophie Croizier, Sevasti Gaspari, David Tarussio, Bernard Thorens   +5 more
doaj   +1 more source

Intracellular Ca2+ dynamics in the ALA neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans

iScience, 2022
Summary: The mechanisms underlying sleep homeostasis are poorly understood. The nematode Caenorhabditis elegans exhibits 2 types of sleep: lethargus, or developmentally timed, and stress-induced sleep.
Shinichi Miyazaki, Taizo Kawano, Masashi Yanagisawa, Yu Hayashi   +3 more
doaj   +1 more source

Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region

iScience, 2023
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal
Lujia Chen, Xiaoxiao Lin, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu   +6 more
doaj   +1 more source

Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

iScience, 2020
Summary: Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impairment.
Sara Hijazi, Tim S. Heistek, Rolinka van der Loo, Huibert D. Mansvelder, August B. Smit, Ronald E. van Kesteren   +5 more
doaj   +1 more source

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System

iScience, 2020
Summary: Extracellular vesicles (EVs) are important mediators of intercellular communication. Interest in the role of central nervous system (CNS)-derived EVs has been increasing; however, some skepticism of their importance has persisted because many ...
David R. Graykowski, Yi-Zhi Wang, Arun Upadhyay, Jeffrey N. Savas   +3 more
doaj   +1 more source

Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and Brain Damage after Reperfusion in Ischemic Stroke

iScience, 2020
Summary: Astrocytic glycogen is an important energy reserve in the brain and is believed to supply fuel during energy crisis. However, the pattern of glycogen metabolism in ischemic stroke and its potential therapeutic impact on neurological outcomes are
Yanhui Cai, Haiyun Guo, Ze Fan, Xinlei Zhang, Di Wu, Wenhong Tang, Tingting Gu, Shiquan Wang, Anqi Yin, Liang Tao, Xunming Ji, Hailong Dong, Yan Li, Lize Xiong   +13 more
doaj   +1 more source