Results 41 to 50 of about 221,731 (288)

Neuroscience of alcoholism: molecular and cellular mechanisms [PDF]

Cellular and Molecular Life Sciences, 2009
Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of
Sachin, Moonat, Bela G, Starkman, Amul, Sakharkar, Subhash C, Pandey   +3 more
openaire   +2 more sources

Distinct synaptic pools of DAPK1 differentially regulate activity-dependent synaptic CaMKII accumulation

iScience, 2023
Summary: The death-associated protein kinase 1 (DAPK1) regulates the synaptic movement of the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII).
Jonathan E. Tullis, K. Ulrich Bayer
doaj   +1 more source

Substantia nigra modulates breathing rate via locus coeruleus

iScience
Summary: Breathing is an automatic and rhythmic act primarily controlled by hindbrain neural circuits, including the pre-Bötzinger complex. While the basal ganglia are known to regulate a wide range of behaviors through downstream projections, their role
Bon-Mi Gu, Jae Gon Kim, Aronee Hossain, Greg O. Cron, Jin Hyung Lee   +4 more
doaj   +1 more source

Feeding neurons integrate metabolic and reproductive states in mice

iScience, 2023
Summary: Balance between metabolic and reproductive processes is important for survival, particularly in mammals that gestate their young. How the nervous system coordinates this balance is an active area of study.
Megan G. Massa, Rachel L. Scott, Alexandra L. Cara, Laura R. Cortes, Paul B. Vander, Norma P. Sandoval, Jae W. Park, Sahara L. Ali, Leandro M. Velez, Huei-Bin Wang, Shomik S. Ati, Bethlehem Tesfaye, Karen Reue, J. Edward van Veen, Marcus M. Seldin, Stephanie M. Correa   +15 more
doaj   +1 more source

Generation of self-organized autonomic ganglion organoids from fibroblasts

iScience, 2023
Summary: Neural organoids have been shown to serve as powerful tools for studying the mechanism of neural development and diseases as well as for screening drugs and developing cell-based therapeutics. Somatic cells have previously been reprogrammed into
Shuting Liu, Kangjian Xiang, Fa Yuan, Mengqing Xiang   +3 more
doaj   +1 more source

Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life

iScience, 2022
Summary: Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans.
Tristan Fehr, William G.M. Janssen, Janis Park, Mark G. Baxter   +3 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Female mice lacking GluA3 show early onset of hearing loss, cochlear synaptopathy, and afferent terminal swellings in ambient sound levels

iScience
Summary: AMPA-type glutamate receptors (AMPARs) mediate excitatory cochlear transmission. However, unique roles of AMPAR subunits are unresolved. Lack of subunit GluA3 (Gria3KO) in male mice reduced cochlear output by 8 postnatal weeks.
Indra Pal, Atri Bhattacharyya, Babak V-Ghaffari, Essence Devine Williams, Maolei Xiao, Mark Allen Rutherford, María Eulalia Rubio   +6 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Moderate Changes in CO2 Modulate the Firing of Neurons in the VTA and Substantia Nigra

iScience, 2020
Summary: The substantia nigra (SN) and ventral tegmental area (VTA) are vital for the control of movement, goal-directed behavior, and encoding reward.
Emily Hill, Nicholas Dale, Mark J. Wall
doaj   +1 more source