Results 71 to 80 of about 1,773,105 (357)
Journal of Animal Reproduction and Biotechnology, 2018 Polo-like kinase 1 (Plk1) has been known to be a critical element in cell division including centrosome maturation, cytokinesis and spindle formation in somatic, cancer, and mammalian embryonic cells.
Jeonghyeon Moon, Sangho Roh
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Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]
, 2016 Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P +9 more
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Direct cellular reprogramming: the hopes and the hurdles [PDF]
European Journal of Heart Failure, 2016 Comment on Direct cellular reprogramming for cardiac repair and regeneration.
SINAGRA, GIANFRANCO, FABRIS, ENRICO
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The Journal of Reproduction and DevelopmentIn vitro production of porcine-hatched blastocysts is important for various applications. However, the mechanobiology of blastocoel expansion and hatching remains poorly understood.
Ba Anh My LE +6 more
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Cellular decision-making bias: the missing ingredient in cell functional diversity
, 2013 Cell functional diversity is a significant determinant on how biological processes unfold. Most accounts of diversity involve a search for sequence or expression differences. Perhaps there are more subtle mechanisms at work.
Alicea, Bradly
core +2 more sources
Cellular Reprogramming toward the Erythroid Lineage [PDF]
International Journal of Cell Biology, 2011 Haemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden. Currently, the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifically reactivate the production of foetal haemoglobin. These treatments are ongoing throughout the life of
Merlin Crossley +3 more
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Chromatin Connections to Pluripotency and Cellular Reprogramming [PDF]
Cell, 2011 The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory programs that govern self-renewal and differentiation and somatic cell reprogramming. Here, we review the highly connected protein and transcriptional networks that maintain pluripotency and how they are intertwined with factors that affect chromatin ...
Konrad Hochedlinger +2 more
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Diagnostics, 2022 Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases. Symptoms begin with mild memory difficulties and evolve towards cognitive impairment.
Maria-del-Carmen Silva-Lucero +8 more
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, 2015 Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential
Furusawa, Chikara +2 more
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Comparison of Developmental Efficiency of Murine Somatic Cell Nuclear Transfer Protocol
Journal of Animal Reproduction and Biotechnology, 2017 The Somatic cell nuclear transfer (SCNT) method can be applied to various fields such as species conservation, regenerative medicine, farming industries and drug production. However, the efficiency using SCNT is very low for many reasons.
Jeonghyeon Moon, Miran Jung, Sangho Roh
doaj +1 more source