Results 81 to 90 of about 123,953 (269)
Cellular reprogramming dynamics follow a simple one-dimensional reaction coordinate [PDF]
arXiv, 2015 Cellular reprogramming, the conversion of one cell type to another, has fundamentally transformed our conception of cell types. Cellular reprogramming induces global changes in gene expression involving hundreds of transcription factors and thousands of genes and understanding how cells globally alter their gene expression profile during reprogramming ...
arxiv
CLR: Channel-wise Lightweight Reprogramming for Continual Learning [PDF]
arXiv, 2023 Continual learning aims to emulate the human ability to continually accumulate knowledge over sequential tasks. The main challenge is to maintain performance on previously learned tasks after learning new tasks, i.e., to avoid catastrophic forgetting.
arxiv
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Journal of Animal Reproduction and BiotechnologyBackground: Evaluating embryo quality is crucial for the success of in vitro fertilization procedures. Traditional methods, such as the Gardner grading system, rely on subjective human assessment of morphological features, leading to potential ...
Vincent Jaehyun Shim +2 more
doaj +1 more source
Cellular decision-making bias: the missing ingredient in cell functional diversity [PDF]
arXiv, 2013 Cell functional diversity is a significant determinant on how biological processes unfold. Most accounts of diversity involve a search for sequence or expression differences. Perhaps there are more subtle mechanisms at work. Using the metaphor of information processing and decision-making might provide a clearer view of these subtleties.
arxiv
Cell reprogramming design by transfer learning of functional transcriptional networks [PDF]
Proceedings of the National Academy of Sciences, 121(11)
e2312942121 (2024)Recent developments in synthetic biology, next-generation sequencing, and machine learning provide an unprecedented opportunity to rationally design new disease treatments based on measured responses to gene perturbations and drugs to reprogram cells. The main challenges to seizing this opportunity are the incomplete knowledge of the cellular network ...
arxiv +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Engineering extracellular vesicles for ROS scavenging and tissue regeneration
Nano ConvergenceStem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate ...
Ahmed Abdal Dayem +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric +11 more
wiley +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source