Results 11 to 20 of about 266,950 (336)
CELLULAR SENESCENCE, AGING AND CANCER [PDF]
The Scientific World JOURNAL, 2001 INTRODUCTION. Mammalian cells can respond to damage or stress by entering a state of irreversibly arrested growth and altered function termed cellular senescence. The senescence response can be elicited by one or more critically short telomere (replicative senescence), certain types of DNA damage or changes in chromatin structure, the expression of ...
Judith Campisi
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On the evolution of cellular senescence [PDF]
Aging Cell, 2020 AbstractThe idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age‐related diseases and extends the life span of mice. While efforts proceed to make therapeutic use of such discoveries, it is important to ask what evolutionary forces might have been behind the ...
Thomas B. L. Kirkwood +4 more
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Current Biology, 2022 Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators.
Varela-Eirín, Marta, Demaria, Marco
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Is “Cellular Senescence” a Misnomer?
GeroScience, 2022 One of the most striking findings in biogerontology in the 2010s was the demonstration that elimination of senescent cells delays many late-life diseases and extends lifespan in mice. This implied that accumulation of senescent cells promotes late-life diseases, particularly through action of senescent cell secretions (the senescence-associated ...
David Gems, Carina Kern
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The Genetics of Cellular Senescence [PDF]
The American Journal of Human Genetics, 1998 the reversible quiescent state that some young cells undergo in the absence of growth factors. The role of replicative senescence in aging of the organism remains controversial, but correlative evidence suggests that it is an in vitro manifestation of an in vivo phenomenon.
Nathalie G. Bérubé +2 more
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Cellular Senescence in Lung Fibrosis [PDF]
International Journal of Molecular Sciences, 2021 Fibrosing interstitial lung diseases (ILDs) are chronic and ultimately fatal age-related lung diseases characterized by the progressive and irreversible accumulation of scar tissue in the lung parenchyma. Over the past years, significant progress has been made in our incomplete understanding of the pathobiology underlying fibrosing ILDs, in particular ...
Fernanda Hernandez-Gonzalez +5 more
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Frontiers in Physiology, 2021 Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when it is dysregulated.
Xinghui Sun +3 more
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Cell Death and Disease, 2022 During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression.
Paula Carpintero-Fernández +10 more
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Cellular Senescence in the Kidney [PDF]
Journal of the American Society of Nephrology, 2019 Senescent cells have undergone permanent growth arrest, adopt an altered secretory phenotype, and accumulate in the kidney and other organs with ageing and injury. Senescence has diverse physiologic roles and experimental studies support its importance in nephrogenesis, successful tissue repair, and in opposing malignant transformation. However, recent
Marie-Helena Docherty +3 more
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Cellular senescence in neuroblastoma
British Journal of Cancer, 2022 Neuroblastoma is a tumour that arises from the sympathoadrenal lineage occurring predominantly in children younger than five years. About half of the patients are diagnosed with high-risk tumours and undergo intensive multi-modal therapy. The success rate of current treatments for high-risk neuroblastoma is disappointingly low and survivors suffer from
Sofia Zanotti +5 more
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