Results 21 to 30 of about 234,206 (306)

Potential Role of Cellular Senescence in Asthma

Frontiers in Cell and Developmental Biology, 2020
Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation.
Zhao-Ni Wang, Zhao-Ni Wang, Ruo-Nan Su, Bi-Yuan Yang, Ke-Xin Yang, Li-Fen Yang, Yan Yan, Yan Yan, Zhuang-Gui Chen   +8 more
doaj   +1 more source

Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration

Antioxidants, 2022
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases.
Ryo Terao, Tazbir Ahmed, Ayana Suzumura, Hiroko Terasaki   +3 more
doaj   +1 more source

Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis

Biomedicines, 2023
Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic and extrinsic stressors. Cellular senescence results in impaired tissue repair and remodeling, loss of physiological integrity, organ dysfunction, and changes in
Georgia Bateman, Hong Guo-Parke, Aoife M. Rodgers, Dermot Linden, Melanie Bailey, Sinéad Weldon, Joseph C. Kidney, Clifford C. Taggart   +7 more
doaj   +1 more source

Role of hypoxia in cellular senescence

Pharmacological Research, 2023
Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling molecules that poison surrounding cells, leading to various age-related diseases, including diabetes, atherosclerosis, and Alzheimer’s disease.
Haoyu Gao, Eugenie Nepovimova, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca, Vojtech Adam   +6 more
doaj   +1 more source

Cellular senescence: a double-edged sword in cancer therapy

Frontiers in Oncology, 2023
Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stresses.
Shuai Xiao, Dongmin Qin, Xueyang Hou, Lingli Tian, Yeping Yu, Rui Zhang, Rui Zhang, Hao Lyu, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang   +11 more
doaj   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

Frontiers in Cell and Developmental Biology, 2022
It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of
Tomoaki Hishida, Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Yuto Takemoto, Fumiyuki Hatanaka, Kei Yoshida, Javier Prieto, Sanjeeb Kumar Sahu, Yuta Takahashi, Pradeep Reddy, David D. O’Keefe, Concepcion Rodriguez Esteban, Paul S. Knoepfler, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Ryuji Kato, Hiroshi Nakagawa, Hiroshi Nakagawa, Juan Carlos Izpisua Belmonte   +20 more
doaj   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Rapamycin decelerates cellular senescence [PDF]

Cell Cycle, 2009
When the cell cycle is arrested but cellular growth is not, then cells senesce, permanently losing proliferative potential. Here we demonstrated that the duration of cell cycle arrest determines a progressive loss of proliferative capacity. In human and rodent cell lines, rapamycin (an inhibitor of mTOR) dramatically decelerated loss of proliferative ...
Zoya N, Demidenko, Svetlana G, Zubova, Elena I, Bukreeva, Valery A, Pospelov, Tatiana V, Pospelova, Mikhail V, Blagosklonny   +5 more
openaire   +2 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source