Results 41 to 50 of about 266,950 (336)

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours [PDF]

, 2015
Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy.
Alajati, Abdullah, Alimonti, Andrea, Brambilla, Lara, Carbone, Giuseppina, Catapano, Carlo V., Chen, Jingjing, Cozza, Giorgio, Danzer Baltzer, Claudia, Delaleu, Nicolas, Di Mitri, Diletta, Frew, Ian J., Garcia Escudero, R., Guccini, Ilaria, Kalathur, Madhuri, Kalathur, Ravi Kiran Reddy, Maccari, Laura, Magnoni, Letizia, Malusa, Federico, Padova, Alessandro, Pinna, Lorenzo A., Pinton, Sandra, Revandkar, Ajinkya, Ruzzene, Maria, Sarti, Manuela, Tarditi, Alessia, Toso, Alberto   +25 more
core   +1 more source

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

Frontiers in Cell and Developmental Biology, 2022
It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of
Tomoaki Hishida, Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Yuto Takemoto, Fumiyuki Hatanaka, Kei Yoshida, Javier Prieto, Sanjeeb Kumar Sahu, Yuta Takahashi, Pradeep Reddy, David D. O’Keefe, Concepcion Rodriguez Esteban, Paul S. Knoepfler, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Ryuji Kato, Hiroshi Nakagawa, Hiroshi Nakagawa, Juan Carlos Izpisua Belmonte   +20 more
doaj   +1 more source

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]

, 2015
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B., Haferkamp, S., Hufnagel, A.L., Kneitz, S., Leikam, C., Meierjohann, S., Murphy, D.J., Mühling, B., Nanda, I., Otto, C., Schartl, M., Schmid, M., Wagner, T.U.   +12 more
core   +2 more sources

Therapeutic targeting of replicative immortality [PDF]

, 2015
One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and therapeutic ...
Amedei, Amedeo, Amin, Amr, Aquilano, Katia, Ashraf, S. Salman, Azmi, Asfar S., Bhakta, Dipita, Bilsland, Alan, Boosani, Chandra S., Carnero, Amancio, Chen, Sophie, Ciriolo, Maria Rosa, Firestone, Gary L., Fujii, Hiromasa, Georgakilas, Alexandros G., Guhan, Anur, Halicka, Dorota, Helferich, Bill, Hentosh, Patricia, Honoki, Kanya, Keith, W. Nicol, MacKenzie, Karen L., Matheu, Ander, Mohammed, Sulma I., Niccolai, Elena, Nowsheen, Somaira, Rodier, Francis, Sundin, Tabetha, Yang, Xujuan, Yaswen, Paul, Zhu, Jiyue   +29 more
core   +2 more sources

The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes

Redox Biology, 2021
The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease.
Jorge D. Erusalimsky
doaj  

Cellular Senescence in Brain Aging [PDF]

Frontiers in Aging Neuroscience, 2021
Aging of the brain can manifest itself as a memory and cognitive decline, which has been shown to frequently coincide with changes in the structural plasticity of dendritic spines. Decreased number and maturity of spines in aged animals and humans, together with changes in synaptic transmission, may reflect aberrant neuronal plasticity directly ...
Anna Bielak-Zmijewska, Adam Krzystyniak, Ewa Sikora, Jakub Wlodarczyk, Grazyna Mosieniak, Magdalena Dudkowska, M Wesierska   +6 more
openaire   +4 more sources

B7-H3 suppresses doxorubicin-induced senescence-like growth arrest in colorectal cancer through the AKT/TM4SF1/SIRT1 pathway

Cell Death and Disease, 2021
Emerging evidence suggests that cellular senescence induced by chemotherapy has been recognized as a new weapon for cancer therapy. This study aimed to research novel functions of B7-H3 in cellular senescence induced by a low dose of doxorubicin (DOX) in
Ruoqin Wang, Linqing Sun, Suhua Xia, Hongya Wu, Yanchao Ma, Shenghua Zhan, Guangbo Zhang, Xueguang Zhang, Tongguo Shi, Weichang Chen   +9 more
doaj   +1 more source

The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]

, 2017
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena, Dal Sasso, Eleonora, Forte, Maurizio, Frati, Giacomo, Gerosa, Gino, Iop, Laura, Palmerio, Silvia, Peruzzi, Mariangela, Schirone, Leonardo, Sciarretta, Sebastiano   +9 more
core   +4 more sources

Cellular senescence in asthma: from pathogenesis to therapeutic challenges

EBioMedicine, 2023
Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms ...
Rongjun Wan, Prakhyath Srikaram, Vineeta Guntupalli, Chengping Hu, Qiong Chen, Peisong Gao   +5 more
doaj  

The tumor suppressor ING1 contributes to epigenetic control of cellular senescence [PDF]

, 2010
Cellular senescence is an effective tumor-suppressive mechanism that causes a stable proliferative arrest in cells with potentially oncogenic alterations.
Abad, María Alba, Blanco, Francisco J., Moreno, Alberto, Moreno-Bueno, Gema, Narita, Masako, Narita, Masashi, Palacios, Alicia C., Palmero, Ignacio   +7 more
core   +2 more sources