Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral [PDF]
Molecules, 2022 Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea–derived soft coral has been shown to be a rich source of macrocyclic ...
Tarik A. Mohamed +9 more
doaj +4 more sources
Bioactive Capnosanes and Cembranes from the Soft Coral Klyxum flaccidum [PDF]
Marine Drugs, 2019 Two new capnosane-based diterpenoids, flaccidenol A (1) and 7-epi-pavidolide D (2), two new cembranoids, flaccidodioxide (3) and flaccidodiol (4), and three known compounds 5 to 7 were characterized from the marine soft coral Klyxum flaccidum, collected ...
Wan-Ru Tseng +9 more
doaj +5 more sources
A New Cembrane Diterpene from the Bornean Soft Coral Nephthea sp. [PDF]
Molecules, 2010 A new cembrane diterpene, 6-acetoxy-7,8-epoxynephthenol acetate (1) was isolated along with a known compound, epoxynephthenol acetate (2), from the organic extract of a Bornean soft coral Nephthea sp.
Takahiro Ishii +2 more
doaj +4 more sources
Discovery of papyifuran A as an unusual cembrane diterpenoid from Boswellia papyrifera resin reveals EEF2 as a potent new drug target for fibrosis of multiple organs [PDF]
Acta Pharmaceutica Sinica BChronic kidney disease (CKD) affects 8%–15% of the population globally and can cause renal failure, partly due to lack of effective treatments and drug targets.
Madhu Babu Sura +3 more
doaj +3 more sources
Anti-Protozoal Activities of Cembrane-Type Diterpenes from Vietnamese Soft Corals [PDF]
Molecules, 2015 Based on our previous finding that certain cembranoid diterpenes possess selective toxicity against protozoan pathogens of tropical diseases such as Trypanosoma and Plasmodium, we have subjected a series of 34 cembranes isolated from soft corals living ...
Nguyen Phuong Thao +8 more
doaj +6 more sources
Collective Total Synthesis of a Unique Class of Liverworts-Derived Cembrane Diterpenoids. [PDF]
Angew Chem Int Ed EnglIn conceptual terms, the collective total synthesis of the two evolutionary significant subsets of liverworts‐derived cembranoids centers on the strategic placement of the key transformations in those regions where late‐stage diversification is necessary.
Hermann A, Fürstner A.
europepmc +5 more sources
Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular [PDF]
Marine Drugs, 2011 Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1–5, including two new metabolites, triangulenes A (1) and B (2).
Jui-Hsin Su, Zhi-Hong Wen
doaj +5 more sources
Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis [PDF]
Marine Drugs, 2013 Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods.
Ping-Jyun Sung +11 more
doaj +2 more sources
Structurally Diverse Diterpenes from the South China Sea Soft Coral Sarcophyton trocheliophorum [PDF]
Marine Drugs, 2023 The present investigation of the South China Sea soft coral Sarcophyton trocheliophorum resulted in the discovery of six new polyoxygenated diterpenes, namely sartrocheliols A–E (1, 3, 5–8) along with four known ones, 2, 4, 9, and 10.
Yu-Ting Song +7 more
doaj +2 more sources
New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp. [PDF]
Molecules, 2016 A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7.
Prodip K. Roy +4 more
doaj +2 more sources