Exploration of anti‐leukemic effect of soft coral‐derived 13‐acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II [PDF]
Kaohsiung Journal of Medical Sciences, 2023 13‐Acetoxysarcocrassolide (13‐AC) is a marine cembranoid derived from the aquaculture soft coral of Lobophytum crassum. The cytotoxic effect of 13‐AC against leukemia cells was previously reported but its mechanism of action is still unexplored.
Hsien‐Kuo Chin +10 more
doaj +3 more sources
Pharmacokinetics and Metabolism of 4R-Cembranoid. [PDF]
PLoS ONE, 2015 4R-cembranoid (4R) is a natural cyclic diterpenoid found in tobacco leaves that displays neuroprotective activity. 4R protects against NMDA, paraoxon (POX), and diisopropylfluorophosphate (DFP) damage in rat hippocampal slices and against DFP in rats in ...
Wanda Vélez-Carrasco +6 more
doaj +5 more sources
Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule [PDF]
Marine DrugsCembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds.
Hanyang Peng +9 more
doaj +2 more sources
A Review on Bioactivities of Tobacco Cembranoid Diterpenes [PDF]
Biomolecules, 2019 Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring.
Ning Yan +5 more
doaj +3 more sources
Formation of α- and β-Cembratriene-Diols in Tobacco (Nicotiana tabacum L.) Is Regulated by Jasmonate-Signaling Components via Manipulating Multiple Cembranoid Synthetic Genes [PDF]
Molecules, 2018 Cembranoids are a group of natural diterpenoid compounds with pharmaceutical potentials, and the cembratriene-diols produced by Nicotiana (tobacco) species display activities in anti-nicotine addiction and neuron protection.
Jinkai Sui +12 more
doaj +2 more sources
Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum [PDF]
Marine Drugs, 2018 Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A–C (1–3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7–16) from the ethyl acetate (EtOAc ...
Atallah F. Ahmed +7 more
doaj +2 more sources
Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum [PDF]
Marine Drugs, 2014 Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data.
Shi-Yie Cheng +2 more
doaj +2 more sources
Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans [PDF]
Marine Drugs, 2013 Four new cembrane-type diterpenoids, sarcophyolides B–E (1–4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1–4 were established on the basis of spectroscopic analysis and chemical ...
Leen van Ofwegen +6 more
doaj +2 more sources
Antibacterial Methyl Ester Cembranoids from the Soft Coral Sarcophyton ehrenbergi and Their Structural Elucidation [PDF]
Marine DrugsSix previously undescribed methyl ester cembranoids, namely sarcoehrenolides L–Q (1–6), along with three known related ones (7–9), were isolated from the soft coral Sarcophyton ehrenbergi collected off Weizhou Island in the South China Sea.
Meng-Jun Wu +4 more
doaj +2 more sources
Isosarcophytoxide Derivatives with a 2,5-Dihydrofuran Moiety from the Soft Coral Sarcophyton cinereum [PDF]
Molecules, 2023 The present chemical investigation on the organic extract of the soft coral Sarcophyton cinereum has contributed to the isolation of four new cembranoids: 16β- and 16α-hydroperoxyisosarcophytoxides (1 and 2), 16β- and 16α-methoxyisosarcophytoxides (3 and
Chih-Hua Chao +9 more
doaj +2 more sources