Results 31 to 40 of about 918 (174)

Bioactive Natural, Biocatalytic, and Semisynthetic Tobacco Cembranoids

Planta Medica, 2010
The two major Nicotiana tabacum tobacco cembranoids, (1 S,2 E,4 R,6 R,7 E,11 E)-2,7,11-cembratriene-4,6-diol (1) and its C-4 epimer, exhibit a wide range of interesting biological activities. Although the tumorigenesis inhibition activity of tobacco cembranoids have been known since the mid 1980's, only a limited number of investigations have targeted ...
Hany N, Baraka, Mohammad A, Khanfar, John C, Williams, Emad M, El-Giar, Khalid A, El Sayed   +4 more
  +6 more sources

Structural Modifications and Biological Activities of Natural α- and β-Cembrenediol: A Comprehensive Review

Pharmaceuticals, 2022
As one of the most characteristic ingredients of glandular trichome secretions from Nicotiana tabacum L. (tobacco), natural cembrenediols, namely, (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol (α-cembrenediol/α-CBD) and its C-4 epimer (β-cembrenediol/
Kuo Xu, Xinying Du, Xia Ren, XiuXue Li, Hui Li, Xianjun Fu, Xiaoyi Wei   +6 more
doaj   +1 more source

A Vicinal Diol Approach for the Total Synthesis of Molestin E, ent‐Sinulacembranolide A and ent‐Sinumaximol A

Chemistry – A European Journal, Volume 28, Issue 63, November 11, 2022., 2022
The convergent total synthesis of furanocembranoids (FC) molestin E, ent‐sinulacembranolide A and ent‐sinumaximol A was achieved in 20–21 steps in the longest linear sequence (LLS). Building blocks were coupled through a furan metalation sequence and macrocycle formation was effected by Shiina lactonisation. The primary target molestin E was elaborated
Oskar Hoff, Nicolas Kratena, Daniya Aynetdinova, Kirsten E. Christensen, Timothy J. Donohoe   +4 more
wiley   +1 more source

Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development

ChemMedChem, Volume 17, Issue 12, June 20, 2022., 2022
C−H bond oxyfunctionalisation is a significant challenge in organic synthetic chemistry. In drug discovery and development, exploiting biocatalytic methods which can introduce hydroxyl groups deftly with high selectivity, under mild conditions, is of paramount interest.
Sacha N. Charlton, Martin A. Hayes
wiley   +1 more source

The chemotype core collection of genus Nicotiana

The Plant Journal, Volume 110, Issue 5, Page 1516-1528, June 2022., 2022
SUMMARY Sustainable production of chemicals and improving these biosources by engineering metabolic pathways to create efficient plant‐based biofactories relies on the knowledge of available chemical/biosynthetic diversity present in the plant. Nicotiana species are well known for their amenability towards transformation and other new plant breeding ...
Margit Drapal, Eugenia M. A. Enfissi, Paul D. Fraser   +2 more
wiley   +1 more source

Anti-Inflammatory Cembranoids from a Formosa Soft Coral Sarcophyton cherbonnieri

Marine Drugs, 2020
The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F–L (1–7).
Chia-Chi Peng, Chiung-Yao Huang, Atallah F. Ahmed, Tsong-Long Hwang, Jyh-Horng Sheu   +4 more
doaj   +1 more source

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae)

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022
Croton gratissimus is an important plant in Africa setup and across the globe for its ethnomedicinal uses in managing a wide range of diseases. Its phylogeny, pharmacological properties, ethnomedicinal uses, phytochemistry, and cytotoxicity have been highlighted in various articles and journals.
Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara, Srinivas Mutalik   +4 more
wiley   +1 more source

Manipulation of CBTS1 Expression Alters Tobacco Resistance to Spodoptera frugiperda and Phytophthora nicotianae

Agronomy, 2023
Cembranoids produced by tobacco glandular trichomes have bioactivities in resistance to insect pests and pathogens. Cembratrien-ol synthase (CBTS) plays a key role in the biosynthesis of cembranoids and directly determines the cembranoid content in ...
Jian Guan, Zaifeng Du, Tian Tian, Wenjing Wang, Fuzhu Ju, Xiaoyang Lin, Zhongfeng Zhang, Yi Cao, Hongbo Zhang   +8 more
doaj   +1 more source

Enzymkatalysierte späte Modifizierungen: Besser spät als nie

Angewandte Chemie, Volume 133, Issue 31, Page 16962-16993, July 26, 2021., 2021
Späte Modifizierungen sind unerlässlich für die Diversifizierung von Verbindungen in der Synthese. Da Enzyme effiziente Werkzeuge für milde, Katalysator‐kontrollierte Funktionalisierungen bieten, sind neue biokatalytische Methoden für eine große Fülle orthogonaler Reaktionen entstanden.
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel   +7 more
wiley   +1 more source

Enzymatic Late‐Stage Modifications: Better Late Than Never

Angewandte Chemie International Edition, Volume 60, Issue 31, Page 16824-16855, July 26, 2021., 2021
Late‐stage modification is an indispensable approach for compound diversification in synthesis. Since enzymes offer particularly powerful means for mild, catalyst‐controlled functionalisations, in recent years several novel biocatalytic methods have emerged enabling a broad array of orthogonal reactions.
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel   +7 more
wiley   +1 more source