Results 161 to 170 of about 751,175 (304)

Development of rosuvastatin calcium nano-carrier patches by central composite design [PDF]

B. Padmaja, S. SHOBHA RANI
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Statistically Optimized Repaglinide-loaded Floating Microspheres for the Gastric Sustained Delivery via Central Composite Design

, 2022
Fatima Z. Badaoui, Slimane M. Feliachi, Fares . Boukehil, Lamine . Gacem   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Optimization of catalytic sono-praxone hybrid process in the presence of iron oxide-zinc oxide catalyst for the treatment of petroleum wastewater by central composite design

, 2022
Mehrab Aghazadeh, Amirhesam Hasani, Mehdi Borghei   +2 more
openalex   +1 more source

Central Composite Design in a Refinery’s Wastewater Treatment by Air Flotation [PDF]

, 2013
Fotis Rigas, P Panteleos, C Laoudis, S Al-Muzaini, H Khordagui, M Hamouda, R Gehr, C Swartz, G Offringa, H Lavallee, J Nadreau, S Liers, J Baeyens, I Mochtar, J Malley, J Edwald, M Valade, J Edzwald, J Tobiason, J Dahlquist, T Hedberg, T Amato, P Woollen   +22 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Modeling and optimization of Multi-Waste foam geopolymers using central composite design and neural networks. [PDF]

Sci Rep
Noui A, Belkadi AA, Berkouche A, Alsuhaibani E, Alomayri T, Dridi M, Douadi A.   +6 more
europepmc   +1 more source

Optimisation of oven-drying of baobab leaves using a central composite design

, 2020
A.M. Gbaguidi, Flora Josiane Chadaré, V.K. Salako, Y.O.V. Idohou, A.E. Assogbadjo   +4 more
openalex   +2 more sources