Results 71 to 80 of about 183,561 (262)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Application of central composite design to optimize the amount of carbon source and prebiotics for Bifidobacterium bifidum BB01

Acta Universitatis Cibiniensis. Series E: Food Technology, 2016
The objective of the present study was to obtain the optimum proportion of the carbon source and prebiotics for Bifidobacterium bifidum BB01 by the central composite design (CCD).
Shu Guowei, Lei Ni, Chen He, Hu Man, Yang Hui   +4 more
doaj   +1 more source

Extraction of total carotenoids from peach palm fruit (Bactris gasipaes) peel by means of ultrasound application and vegetable oil

Dyna, 2019
Ultrasonic-assisted extraction (UAE) was applied to extract total carotenoids from dried peach palm peel using soy oil as extraction solvent. Optimization of UAE parameters of total carotenoid extraction from dried peel was done using Response Surface ...
Jader Martínez Girón, Luis Eduardo Ordoñez Santos, Diana Ximena Rodríguez-Rodríguez   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

An approach to measuring rotatability in central composite designs

International Journal of Advanced Statistics and Probability, 2015
<p>An approach to measure design rotatability and a measure, that quantifies the percentage of rotatability (from 0 to 100) in the central composite designs are introduced. This new approach is quite different from the ones provided by previous authors which assessed design rotatability by the viewing of tediously obtained contour diagrams.
Emmanuel Ohaegbulem, Polycarp Chigbu
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Numerical and experimental investigation of CI engine parameters using palm biodiesel with diesel blends

Scientific Reports
The current study involves the conversion of oil derived from Palm into biodiesel using a two-stage trans esterification process. The physiochemical and filterability characteristics of biodiesels are analyzed and experiments are carried out employing a ...
B. Musthafa, M. Prabhahar
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Otimização de método para determinação de flavonóis e flavonas em frutas por cromatografia líquida de alta eficiência utilizando delineamento estatístico e análise de superfície de resposta Optimization of a method for determination of flavonols and flavones in fruits by HPLC using statistical design and response surface analysis

Química Nova, 2008
This work optimized the HPLC conditions for the simultaneous determination of luteolin, apigenin, myricetin, quercetin and kaempferol in aglycone form, as well defined the best conditions for hydrolysis/extraction of these flavonoids in fruits, using the
Rosemary Hoffmann-Ribani, Delia B. Rodriguez-Amaya   +1 more
doaj   +1 more source