Results 1 to 10 of about 1,539,059 (172)

Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages

Frontiers in Neuroscience, 2021
One of the major challenges in treating Alzheimer's disease (AD) is its early diagnosis. Increasing data from clinical and animal research indicate that the retina may facilitate an early diagnosis of AD. However, a previous study on the 5xFAD (a fast AD
Mengrong Zhang, Liting Zhong, Xiu Han, Guoyin Xiong, Di Xu, Sensen Zhang, Haiyang Cheng, Kin Chiu, Kin Chiu, Ying Xu, Ying Xu, Ying Xu   +11 more
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Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice

Translational Psychiatry, 2023
Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann, Niklas Schuelert, Holger Rosenbrock   +2 more
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HIF-1α participates in secondary brain injury through regulating neuroinflammation

Translational Neuroscience, 2023
A deeper understanding of the underlying biological mechanisms of secondary brain injury induced by traumatic brain injury (TBI) will greatly advance the development of effective treatments for patients with TBI. Hypoxia-inducible factor-1 alpha (HIF-1α)
Xu Xiaojian, Yang Mengshi, Zhang Bin, Dong Jinqian, Zhuang Yuan, Ge Qianqian, Niu Fei, Liu Baiyun   +7 more
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Redox-neutral and metal-free synthesis of 3-(arylmethyl)chroman-4-ones via visible-light-driven alkene acylarylation

Frontiers in Chemistry, 2022
A metal- and aldehyde-free visible-light-driven photoredox-neutral alkene acylarylation with readily available cyanoarenes is described. A variety of 3-(arylmethyl)chroman-4-ones (i.e., homoisoflavonoids) and analogs are efficiently synthesized with good
Yan Ding, Shengjiao Yu, Man Ren, Ji Lu, Qiang Fu, Zhijie Zhang, Qin Wang, Jun Bai, Na Hao, Lin Yang, Siping Wei, Dong Yi, Jun Wei   +12 more
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Age-adjusted D-Dimer Thresholds Combined with the Modified Wells Score as a Predictor of Lower Extremity Deep Venous Thrombosis

Clinical and Applied Thrombosis/Hemostasis, 2023
Background Neurosurgical patients are at an increased risk of deep venous thrombosis (DVT), which, if not properly managed, can lead to pulmonary embolism.
Wei Hao MD, Xuanhui Liu MD, Jiancheng Feng MD, Yu Qian MD, Shuo An MD, Ye Tian MD, Wei Quan MD, Jian Sun MD, Yingsheng Wei MD, Xinjie Zhang MD, Rongcai Jiang MD   +10 more
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MPs-ACT, an Assay to Evaluate the Procoagulant Activity of Microparticles

Clinical and Applied Thrombosis/Hemostasis, 2023
The procoagulant effect of microparticles (MPs) contributes to hypercoagulability-induced thrombosis. We provide preliminary findings of the MPs-Activated Clotting Time (MPs-ACT) assay to determine the procoagulant activity of MPs.
Yalong Gao PhD, Xiaotian Li PhD, Yafei Qin MD, Jianlong Men PhD, Jing Ren PhD, Xiaochun Li MM, Chunlei Xu MD, Qifeng Li PhD, Ying Li PhD, Weiyun Cui MM, Shu Zhang PhD, Lei Li MM, Yaohua Li MD, Jianning Zhang MD, Li Liu PhD   +14 more
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SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas

Frontiers in Oncology, 2021
Patients with germline neurofibromatosis type 1 (NF1) microdeletions frequently exhibit hereditary syndromes such as cardiovascular anomalies and have an increased risk of malignant peripheral nerve sheath tumors (MPNSTs).
Weijie Li, Chenhao Hu, Xingnan Zhang, Binbin Wang, Zhen Li, Miao Ling, Shengqiao Sun, Chao Guo, Dezhi Li, Song Liu, Song Liu   +10 more
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Chemodivergent photocatalytic access to 1-pyrrolines and 1-tetralones involving switchable C(sp3)–H functionalization

Frontiers in Chemistry, 2022
A chemodivergent photocatalytic approach to 1-pyrrolines and 1-tetralones from alkyl bromides and vinyl azides has been developed through chemoselectively controllable intermolecular [3 + 2] and [4 + 2] cyclization.
Shijing Tu, Zhongyu Qi, Weicai Li, Shiqi Zhang, Zhijie Zhang, Jun Wei, Lin Yang, Siping Wei, Xi Du, Dong Yi   +9 more
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A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury

ASN Neuro, 2021
Destabilization of blood vessels by the activities of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) following intracerebral hemorrhage (ICH) has been considered the main causes of aggravated secondary brain injury.
Gui-Li Yang, Shizhao Wang, Shu Zhang, Ye Liu, Xiao Liu, Dong Wang, Huijie Wei, Jianhua Xiong, Zhi-Song Zhang, Zengguang Wang, Lu-Yuan Li, Jianning Zhang   +11 more
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NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury

Frontiers in Immunology, 2022
NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein apoptosis-associated speck-like protein containing a CARD domain, and the effector ...
Liang Mi, Liang Mi, Xiaobin Min, Xiaobin Min, Yan Chai, Jianning Zhang, Jianning Zhang, Xin Chen, Xin Chen   +8 more
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