Results 1 to 10 of about 3,233,933 (403)

Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)

Journal of Medical Virology, 2020
Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe ...
A. Paniz‐Mondolfi, C. Bryce, Z. Grimes, R. Gordon, J. Reidy, J. Lednicky, E. Sordillo, M. Fowkes   +7 more
semanticscholar   +1 more source

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain

Journal of Lipid Research, 2015
The enzyme 12/15-lipoxygenase (LOX) oxidizes various free fatty acids, including arachidonic acid (AA). In the brain, the principal 12/15-LOX metabolites of AA are 12(S)-HETE and 15(S)-HETE. PPARγ is a nuclear receptor whose activation is neuroprotective
Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng   +5 more
doaj   +1 more source

Glucose metabolism: A link between traumatic brain injury and Alzheimer’s disease

Chinese Journal of Traumatology, 2021
Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved.
Xiao-Jian Xu, Meng-Shi Yang, Bin Zhang, Fei Niu, Jin-Qian Dong, Bai-Yun Liu   +5 more
doaj   +1 more source

TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1

Scientific Reports
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell-derived sarcomas that are sporadic or associated with Neurofibromatosis 1 (NF1) gene mutations. Traditional therapies are usually ineffective for treating MPNSTs, so new
Xingnan Zhang, Chenhao Hu, Shengqiao Sun, Chao Guo, Yakun Bu, Zicong Wang, Zewei Liu, Xiaoli Zhang, Dezhi Li, Song Liu   +9 more
doaj   +1 more source

Deep Brain Stimulation for Parkinson’s Disease—A Narrative Review

Biomedicines
Deep brain stimulation (DBS) is an established neurosurgical treatment for Parkinson’s disease (PD), mainly targeting motor symptoms resistant to pharmacological therapy.
Rafał Wójcik, Anna Dębska, Karol Zaczkowski, Bartosz Szmyd, Małgorzata Podstawka, Ernest J. Bobeff, Michał Piotrowski, Paweł Ratajczyk, Dariusz J. Jaskólski, Karol Wiśniewski   +9 more
doaj   +1 more source

Central Nervous System Tuberculosis [PDF]

Baylor University Medical Center Proceedings, 2010
Central nervous system tuberculosis is a rare presentation of active tuberculosis and accounts for about 1% of cases (1). The three clinical categories include meningitis, intracranial tuberculomas, and spinal tuberculous arachnoiditis. We report a case of a young man who presented with active pulmonary tuberculosis in addition to tuberculous ...
Vincent C, Kuo, Louis M, Sloan, Michael, Emmett   +2 more
openaire   +2 more sources

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

International Journal of Molecular Sciences, 2018
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2.
Shenglong Zou, U. Kumar
semanticscholar   +1 more source

Atorvastatin combined with dexamethasone in chronic subdural haematoma (ATOCH II): study protocol for a randomized controlled trial

Trials, 2021
Background Chronic subdural haematoma (CSDH) is a common condition in the elderly that often requires neurosurgical management. For small CSDH, evidence has emerged that statins may reduce haematoma volume and improve outcomes, presumably by reducing ...
Rong Cai Jiang, Dong Wang, Shi Guang Zhao, Ren Zhi Wang, De Zhi Kang, Xin Gen Zhu, Zong Mao Zhao, Jun Ji Wei, Ying Huang, Yan Qu, Xiao Chuan Sun, Hong Ming Ji, Xiao Chun Jiang, Jin Fang Liu, Xi De Zhu, Jian Jun Wang, Ye Tian, Chuang Gao, Hui Jie Wei, Shu Zhang, Wei Quan, Shu Yuan Yue, Ping Lei, Xian Li, Li Li Song, Craig S. Anderson, Jian Ning Zhang   +26 more
doaj   +1 more source

Possible mechanism and Atorvastatin-based treatment in cupping therapy-related subdural hematoma: A case report and literature review

Frontiers in Neurology, 2022
Subdural hematoma (SDH) is one of the most lethal types of traumatic brain injury. SDH caused by Intracranial Pressure Reduction (ICPR) is rare, and the mechanism remains unclear. Here, we report three cases of SDH that occurred after substandard cupping
Tangtang Xiang, Tangtang Xiang, Xinjie Zhang, Xinjie Zhang, Yingsheng Wei, Yingsheng Wei, Dongyi Feng, Dongyi Feng, Zhitao Gong, Zhitao Gong, Xuanhui Liu, Xuanhui Liu, Jiangyuan Yuan, Jiangyuan Yuan, Weiwei Jiang, Weiwei Jiang, Meng Nie, Meng Nie, Yibing Fan, Yibing Fan, Yupeng Chen, Yupeng Chen, Jiancheng Feng, Jiancheng Feng, Shiying Dong, Shiying Dong, Chuang Gao, Chuang Gao, Jinhao Huang, Jinhao Huang, Rongcai Jiang, Rongcai Jiang   +31 more
doaj   +1 more source

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

Viruses, 2019
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the ...
M. Desforges, Alain Le Coupanec, Philippe Dubeau, Andréanne Bourgouin, L. Lajoie, M. Dubé, P. Talbot   +6 more
semanticscholar   +1 more source