Results 21 to 30 of about 1,698,859 (327)

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAF V600E /TERT promoter double-mutated glioma

Acta Neuropathologica Communications, 2019
The BRAF gene and the TERT promoter are among the most frequently altered genomic loci in low-grade (LGG) and high-grade-glioma (HGG), respectively.
Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger   +19 more
doaj   +1 more source

Use of a compact high-definition two-dimensional exoscope in surgical treatment of large vestibular schwannoma

Chinese Medical Journal, 2020
. Background:. Extra-corporeal video telescope operating monitor system provides a necessary instrument to perform high-precision neurosurgical procedures that could substitute or supplement the traditional surgical microscope.
Xin Chen, Xiang-Liang Gao, Yan Chai, Ming-Ming Shi, Jian-Ning Zhang, Shu-Yuan Yue, Xiu-Yuan Hao   +6 more
doaj   +1 more source

Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice

Frontiers in Immunology, 2023
IntroductionIncreased neutrophil extracellular trap (NET) formation has been reported to be associated with cerebrovascular dysfunction and neurological deficits in traumatic brain injury (TBI).
Yiyao Cao, Yiyao Cao, Yiyao Cao, Mingming Shi, Mingming Shi, Mingming Shi, Liang Liu, Liang Liu, Liang Liu, Yan Zuo, Haoran Jia, Haoran Jia, Haoran Jia, Xiaobin Min, Xilei Liu, Xilei Liu, Xilei Liu, Zhijuan Chen, Zhijuan Chen, Zhijuan Chen, Yuan Zhou, Yuan Zhou, Yuan Zhou, Shenghui Li, Shenghui Li, Shenghui Li, Guili Yang, Guili Yang, Guili Yang, Xiao Liu, Xiao Liu, Xiao Liu, Quanjun Deng, Quanjun Deng, Quanjun Deng, Fanglian Chen, Fanglian Chen, Xin Chen, Xin Chen, Xin Chen, Shu Zhang, Shu Zhang, Shu Zhang, Jianning Zhang, Jianning Zhang, Jianning Zhang   +45 more
doaj   +1 more source

Tertiary lymphoid organs in central nervous system autoimmunity [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
core   +1 more source

Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu, Huiming Zhang, Tian-Xiang Zhang, Meng Yuan, Chen Du, Pei Zeng, Zhenning Huang, Dongmei Jia, Guili Yang, Fu-Dong Shi, Fu-Dong Shi, Chao Zhang, Chao Zhang   +12 more
doaj   +1 more source

Immunohistochemical demonstration of specific antigens in the human brain fixed in zinc-ethanol-formaldehyde

European Journal of Histochemistry, 2015
Tissue fixation is critical for immunohistochemistry. Recently, we developed a zinc-ethanol-formalin fixative (ZEF), and the present study was aimed to assess the applicability of the ZEF for the human brain histology and immunohistochemistry and to ...
D.E. Korzhevskii, E.G. Sukhorukova, O.V. Kirik, I.P. Grigorev   +3 more
doaj   +1 more source

Efferocytosis in the Central Nervous System [PDF]

Frontiers in Cell and Developmental Biology, 2021
The effective clearance of apoptotic cells is essential for maintaining central nervous system (CNS) homeostasis and restoring homeostasis after injury. In most cases of physiological apoptotic cell death, efferocytosis prevents inflammation and other pathological conditions.
Jiayi Zhao, Weiqi Zhang, Tingting Wu, Hongyi Wang, Jialiang Mao, Jian Liu, Ziheng Zhou, Xianfeng Lin, Huige Yan, Qingqing Wang   +9 more
openaire   +3 more sources

A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022
Abstract Objective Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.
Jiayi Song, Jiahui Xu, Wei Yuan, Ruixue Li, Hui Guo, Hanshu Gao, Cuiying Gu, Wenjing Feng, Yanan Ma, Haiqiang Guo, Zhaoqing Sun, Liqiang Zheng   +11 more
wiley   +1 more source

DNA Methylation Associates With Clinical Courses of Atypical Meningiomas: A Matched Case–Control Study

Frontiers in Oncology, 2022
BackgroundAccounting for 15–20% of all meningiomas, WHO grade II meningiomas represent an intermediate group regarding risk of tumor recurrence. However, even within this subgroup varying clinical courses are observed with potential occurrence of ...
Matthias Millesi, Matthias Millesi, Alice Senta Ryba, Alice Senta Ryba, Johannes A. Hainfellner, Johannes A. Hainfellner, Thomas Roetzer, Thomas Roetzer, Anna Sophie Berghoff, Anna Sophie Berghoff, Matthias Preusser, Matthias Preusser, Gerwin Heller, Gerwin Heller, Erwin Tomasich, Erwin Tomasich, Felix Sahm, Felix Sahm, Karl Roessler, Karl Roessler, Stefan Wolfsberger, Stefan Wolfsberger   +21 more
doaj   +1 more source

Effects of pregnancy on neuromyelitis optica spectrum disorder and predictors of related attacks

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1918-1925, December 2022., 2022
Abstract Objective Our study aimed to investigate the influence of pregnancy on the course of neuromyelitis optica spectrum disorders (NMOSD) and to explore the independent predictors of pregnancy‐related attacks. Methods We performed a retrospective study of patients with NMOSD based on the Wingerchuk 2006 or the revised Wingerchuk 2015 criteria ...
Qin Du, Ziyan Shi, Hongxi Chen, Ying Zhang, Yuhan Qiu, Yanlin Lang, Lingyao Kong, Hongyu Zhou   +7 more
wiley   +1 more source