Results 21 to 30 of about 3,233,933 (403)

Brainstem syndrome at onset is related to an early MS diagnosis in Peru: A national referral center cohort

Heliyon, 2021
Background: MS is unpredictable regarding clinical symptoms; however, certain symptoms represent the preferred localization of white matter lesions such as brainstem, spinal cord; or optic nerve.
César Caparó-Zamalloa, Sheila Castro-Suarez, Jaqueline Cortez-Escalante, Wilfor Aguirre-Quispe, Erik Guevara-Silva, Victor Osorio-Marcatinco, María Meza-Vega   +6 more
doaj   +1 more source

MPs-ACT, an Assay to Evaluate the Procoagulant Activity of Microparticles

Clinical and Applied Thrombosis/Hemostasis, 2023
The procoagulant effect of microparticles (MPs) contributes to hypercoagulability-induced thrombosis. We provide preliminary findings of the MPs-Activated Clotting Time (MPs-ACT) assay to determine the procoagulant activity of MPs.
Yalong Gao PhD, Xiaotian Li PhD, Yafei Qin MD, Jianlong Men PhD, Jing Ren PhD, Xiaochun Li MM, Chunlei Xu MD, Qifeng Li PhD, Ying Li PhD, Weiyun Cui MM, Shu Zhang PhD, Lei Li MM, Yaohua Li MD, Jianning Zhang MD, Li Liu PhD   +14 more
doaj   +1 more source

Central Nervous System Cancers [PDF]

Journal of the National Comprehensive Cancer Network, 2013
Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma ...
Nabors, Louis Burt, Ammirati, Mario, Bierman, Philip J, Brem, Henry, Butowski, Nicholas, Chamberlain, Marc C, DeAngelis, Lisa M, Fenstermaker, Robert A, Friedman, Allan, Gilbert, Mark R, Hesser, Deneen, Holdhoff, Matthias, Junck, Larry, Lawson, Ronald, Loeffler, Jay S, Maor, Moshe H, Moots, Paul L, Morrison, Tara, Mrugala, Maciej M, Newton, Herbert B, Portnow, Jana, Raizer, Jeffrey J, Recht, Lawrence, Shrieve, Dennis C, Sills, Allen K, Tran, David, Tran, Nam, Vrionis, Frank D, Wen, Patrick Y, McMillian, Nicole, Ho, Maria   +30 more
openaire   +4 more sources

Age-adjusted D-Dimer Thresholds Combined with the Modified Wells Score as a Predictor of Lower Extremity Deep Venous Thrombosis

Clinical and Applied Thrombosis/Hemostasis, 2023
Background Neurosurgical patients are at an increased risk of deep venous thrombosis (DVT), which, if not properly managed, can lead to pulmonary embolism.
Wei Hao MD, Xuanhui Liu MD, Jiancheng Feng MD, Yu Qian MD, Shuo An MD, Ye Tian MD, Wei Quan MD, Jian Sun MD, Yingsheng Wei MD, Xinjie Zhang MD, Rongcai Jiang MD   +10 more
doaj   +1 more source

SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas

Frontiers in Oncology, 2021
Patients with germline neurofibromatosis type 1 (NF1) microdeletions frequently exhibit hereditary syndromes such as cardiovascular anomalies and have an increased risk of malignant peripheral nerve sheath tumors (MPNSTs).
Weijie Li, Chenhao Hu, Xingnan Zhang, Binbin Wang, Zhen Li, Miao Ling, Shengqiao Sun, Chao Guo, Dezhi Li, Song Liu, Song Liu   +10 more
doaj   +1 more source

A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury

ASN Neuro, 2021
Destabilization of blood vessels by the activities of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) following intracerebral hemorrhage (ICH) has been considered the main causes of aggravated secondary brain injury.
Gui-Li Yang, Shizhao Wang, Shu Zhang, Ye Liu, Xiao Liu, Dong Wang, Huijie Wei, Jianhua Xiong, Zhi-Song Zhang, Zengguang Wang, Lu-Yuan Li, Jianning Zhang   +11 more
doaj   +1 more source

Chemodivergent photocatalytic access to 1-pyrrolines and 1-tetralones involving switchable C(sp3)–H functionalization

Frontiers in Chemistry, 2022
A chemodivergent photocatalytic approach to 1-pyrrolines and 1-tetralones from alkyl bromides and vinyl azides has been developed through chemoselectively controllable intermolecular [3 + 2] and [4 + 2] cyclization.
Shijing Tu, Zhongyu Qi, Weicai Li, Shiqi Zhang, Zhijie Zhang, Jun Wei, Lin Yang, Siping Wei, Xi Du, Dong Yi   +9 more
doaj   +1 more source

miR-19a/b promote EMT and proliferation in glioma cells via SEPT7-AKT-NF-κB pathway

Molecular Therapy: Oncolytics, 2021
miR-19a/b belong to the miR-17-92 family. We have demonstrated previously that miR-19a/b are overexpressed in glioma and glioma cell lines. However, the role of miR-19a/b in glioma remains unclear.
Weihan Wang, Yubing Hao, Anling Zhang, Weidong Yang, Wei Wei, Guangxiu Wang, Zhifan Jia   +6 more
doaj   +1 more source

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAF V600E /TERT promoter double-mutated glioma

Acta Neuropathologica Communications, 2019
The BRAF gene and the TERT promoter are among the most frequently altered genomic loci in low-grade (LGG) and high-grade-glioma (HGG), respectively.
Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger   +19 more
doaj   +1 more source

Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons

Molecular Brain, 2021
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs), and, in turn, provide feedback inhibition onto PC dendrites.
Anne-Sophie Racine, François-Xavier Michon, Isabel Laplante, Jean-Claude Lacaille   +3 more
doaj   +1 more source