Results 61 to 70 of about 2,021,144 (357)

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Clinical Characteristics of Mild Patients with Breakthrough Infection of Omicron Variant in China after Relaxing the Dynamic Zero COVID-19 Policy

Vaccines, 2023
For SARS-CoV-2 mutants, the effectiveness of the COVID-19 vaccines is still controversial. In this study, we aimed to investigate the clinical characteristics of Omicron-infected patients who completed primary immunization and booster immunization ...
Yingyu He, Fang Zhang, Yan Liu, Zhou Xiong, Shangen Zheng, Wanbing Liu, Lei Liu   +6 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Central Nervous System Cancers [PDF]

Journal of the National Comprehensive Cancer Network, 2013
Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma ...
Nabors, Louis Burt, Ammirati, Mario, Bierman, Philip J, Brem, Henry, Butowski, Nicholas, Chamberlain, Marc C, DeAngelis, Lisa M, Fenstermaker, Robert A, Friedman, Allan, Gilbert, Mark R, Hesser, Deneen, Holdhoff, Matthias, Junck, Larry, Lawson, Ronald, Loeffler, Jay S, Maor, Moshe H, Moots, Paul L, Morrison, Tara, Mrugala, Maciej M, Newton, Herbert B, Portnow, Jana, Raizer, Jeffrey J, Recht, Lawrence, Shrieve, Dennis C, Sills, Allen K, Tran, David, Tran, Nam, Vrionis, Frank D, Wen, Patrick Y, McMillian, Nicole, Ho, Maria   +30 more
openaire   +5 more sources

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers

Cancer Cell International, 2021
Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function of the CTHRC1
Dazhao Peng, Cheng Wei, Xiaoyang Zhang, Shenghui Li, Hao Liang, Xingyu Zheng, Shulong Jiang, Lei Han   +7 more
doaj   +1 more source

Cadmium promotes ferroptosis in renal tubular epithelial cells by inducing autophagy

陆军军医大学学报, 2022
Objective To investigate the role of ferritinophagy-mediated ferroptosis in renal tubular epithelial cytotoxicity induced by cadmium (Cd) exposure. Methods HK-2 cells were used to construct Cd exposed cell model, and the effects of Cd on ferroptosis ...
LI Min, LI Min, YANG Qian, YANG Qian
doaj   +1 more source

CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010.

Neuro-Oncology, 2013
T he objective of CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010 is to provide a current comprehensive review of the descriptive epidemiology of primary brain and central nervous ...
Q. Ostrom, H. Gittleman, Paul Farah, A. Ondracek, Yanwen Chen, Yingli Wolinsky, N. E. Stroup, C. Kruchko, J. Barnholtz-Sloan   +8 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas

Frontiers in Immunology, 2022
BackgroundAlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase associated with the development, growth, and progression of multiple cancer types.
Cheng Wei, Bo Wang, Dazhao Peng, Xiaoyang Zhang, Zesheng Li, Lin Luo, Yingjie He, Hao Liang, Xuezhi Du, Shenghui Li, Shu Zhang, Zhenyu Zhang, Lei Han, Jianning Zhang   +13 more
doaj   +1 more source