Results 61 to 70 of about 647,830 (291)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Machine learning models for predicting extended length of stay and hospital charges in nontraumatic subarachnoid hemorrhage

Frontiers in Neurology
BackgroundNontraumatic subarachnoid hemorrhage (SAH) is a critical condition requiring prolonged hospitalization and significant healthcare costs. Identifying factors contributing to extended length of stay (LOS) and predicting associated hospital ...
Di Wu, Di Wu, Sihan Wang, Sihan Wang, Cong Wang, Cong Wang, Yijia Xiang, Lingyu Hao, Zhen Wang, Zhen Wang, Xingye Zhai, Xingye Zhai, Yi Wang, Yi Wang   +13 more
doaj   +1 more source

Immunopathogenesis of infectious-inflammatory diseases of central nervous system

Журнал инфектологии, 2014
The revue includes the contemporary information about the role of resident cells of the CNS (astrocytes, microglia) in development of innate immune response against pathogen (or its products) invasion in the brain.
G. F. Zheleznikova, N. V. Skripchenko
doaj   +1 more source

Huntington's disease: An immune perspective [PDF]

, 2011
Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Kishore, U, Domenico Marco Bonifati, Ansar, R, Verma, SK, Rafia Ansar, Nayak, A, Sunil K. Verma, Annapurna Nayak, Bonifati, DM, Uday Kishore   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Innate Lymphoid Cells in the Central Nervous System

, 2022
International audienceImmune cells are present within the central nervous system and play important roles in neurological inflammation and disease. As relatively new described immune cell population, Innate Lymphoid Cells are now increasingly recognized ...
van de Pavert, Serge A, van de Pavert, Serge, Wang, Shuaiwei   +2 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Histopathological Frequency of Central Nervous System Diseases

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College
Objective: To determine the frequency of central nervous system diseases, both neoplastic and nonneoplastic, by methodically examining data from various age and gender groups.
Prih Bashir, Noshaba Rahat, Humera Shahzad, Asma Jalbani, Zumeud Momin, Farhana Zulfiqar   +5 more
doaj   +1 more source

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration [PDF]

, 2013
Microglia, the resident immune cells of the central nervous system (CNS), play an important role in CNS homeostasis during development, adulthood and ageing.
Perry, V. Hugh, Teeling, Jessica, Jessica Teeling, V. Hugh Perry   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source