Results 51 to 60 of about 621,264 (252)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source
Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel +15 more
wiley +1 more source
Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System
Micromachines, 2020 Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for ...
Mihyeon Bae +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Hydrazine-mediated carbonyl–alkyne/allene reductive olefination
Nature CommunicationsCycloolefin is a privileged motif with significant implications across multiple disciplines. While cycloolefination represents the most unified disconnection strategy, the corresponding approaches are notably scarce.
Linjun Qi +4 more
doaj +1 more source
The complement system in central nervous system diseases
Autoimmunity, 2006 The activation of complement system is important factor in inflammatory, neurodegenerative and cerebrovascular diseases. CNS cells are able to synthesize complement components, and myelin and oligodendrocytes (OLG) are known to activate the classical pathway of complement in vitro in the absence of antibodies.
Horea, Rus +3 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior +11 more
wiley +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Although significant progress has been made in childhood leukemia survival, healthcare providers, and caregivers often face challenges in explaining this disease to patients. Disease‐targeted storybooks have been proposed as a tool to facilitate the understanding of diagnoses and treatment.
Nutvipha Ummartyotin +6 more
wiley +1 more source
Spectrum of acute central nervous system demyelinating diseases [PDF]
Perspectives In Medical Research, 2017 Central nervous system(CNS) demyelinative diseases are mainly Multiple Sclerosis, Acute Disseminated Encephalomyelitis (ADEM), Acute hemorrhagic Leucoencephalitis (AHL). Multiple Sclerosis is the most common.
Bharathkanth Reddy M1 , Ranjith Kumar P2 , P.L John Israel3
doaj