Results 51 to 60 of about 647,830 (291)
Scientific ReportsMyotonic dystrophy type 1 (DM1) is a genetic disease which affects multiple systems including the central nervous system. One of its key neuroimaging biomarkers are white matter hyperintensities (WMHs). The clinical relevance of WMHs remains unclear, and
Marina Di Stefano +7 more
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Biomarkers in autoimmune diseases of the central nervous system
Frontiers in Immunology, 2023 The autoimmune diseases of the central nervous system (CNS) represent individual heterogeneity with different disease entities. Although clinical and imaging features make it possible to characterize larger patient cohorts, they may not provide ...
Fenghe Zhang +4 more
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, 2014 123I-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) is used to evaluate the cerebral blood flow (CBF) in patients with either cerebrovascular or neurodegenerative diseases [3 6].
SHIBATA Yasushi, Yasushi Shibata
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Carbon EnergyThe development of efficient photocatalytic systems for antibiotic degradation remains hindered by the inherent limitations of conventional heterojunctions, particularly the rapid charge recombination associated with Type‐I band alignments.
Yanxian Jin +9 more
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Functions and effects of creatine in the central nervous system
, 2008 Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell, creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption to efficiently regenerate ATP in situ via phosphocreatine or at ...
Schlattner, Uwe +11 more
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The peripheral nervous system and the pathogenesis of prion diseases. [PDF]
, 2004 Prion diseases are inevitably fatal neurodegenerative conditions which affect humans and a wide variety of animals. Unlike other protein aggregation diseases such as Alzheimer's, Parkinson's, and polyglutamine repeat diseases, prion diseases are unique ...
Giger, O +3 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases
, 2016 The nuclear hormone receptor (NHR) superfamily is composed of a wide range of receptors involved in a myriad of important biological processes, including development, growth, metabolism, and maintenance.
Oscar Andrés Moreno-Ramos +5 more
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