Results 111 to 120 of about 151,906 (302)

Viral delivery of a microRNA to Gba to the mouse central nervous system models neuronopathic Gaucher disease

Neurobiology of Disease, 2019
Pathological mutations in GBA, encoding lysosomal glucocerebrosidase (GCase), cause Gaucher disease (GD). GD is a multi-system disease with great phenotypic variation between individuals. It has been classified into type 1 with primarily peripheral involvement and types 2 and 3 with varying degrees of neurological involvement.
Kasey L. Jackson, Catherine Viel, Jennifer Clarke, Jie Bu, Monyrath Chan, Bing Wang, Lamya S. Shihabuddin, S. Pablo Sardi   +7 more
openaire   +3 more sources

IgG-index predicts neurological morbidity in patients with infectious central nervous system diseases

, 2010
Background Prognosis assessment of patients with infectious and neoplastic disorders of the central nervous system (CNS) may still pose a challenge.
Bettina Pfausler, Guengoer Elif, Lackner Peter, Ronny Beer, Peter Lackner, Elif Guengoer, Helbok Raimund, Erich Schmutzhard, Beer Ronny, Schmutzhard Erich, Broessner Gregor, Pfausler Bettina, Gregor Broessner, Raimund Helbok, Florian Deisenhammer, Deisenhammer Florian   +15 more
core   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Kishore, U, Domenico Marco Bonifati, Abhishek Shastri, Shastri, A, Bonifati, DM, Uday Kishore   +5 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

The janus face of serotonin: Regenerative promoter and chronic liver disease aggravator

Heliyon
The progression of liver diseases, from viral hepatitis and fatty liver disease to cirrhosis and hepatocellular carcinoma (HCC), is the most representative series of pathological events in liver diseases.
Benliang Mao, Shoupei Liu, Shanfei Zhu, Fan Wu, Wei Yuan, Yong Yan, Bailin Wang   +6 more
doaj   +1 more source

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

Molecular Neurodegeneration, 2009
Autophagy is the major pathway involved in the degradation of proteins and organelles, cellular remodeling, and survival during nutrient starvation.
Jaeger Philipp A, Wyss-Coray Tony
doaj   +1 more source

How to Spot Symptoms of Acute Flaccid Myelitis in Your Child [PDF]

Acute flaccid myelitis, or AFM, is an uncommon but serious condition that affects the nervous system.LC 10/15/21afm-symptoms-infographic ...

core  

Tenascin-C in patients with central nervous system infections

BackgroundThe extracellular matrix protein tenascin-C has been discovered to be an important regulator of the response to tissue injury and repair in cerebrovascular diseases. This study investigated if tenascin-C is released in response to infections in
Thomsen, Martin Munthe, Zachariassen, Morten, Trier-Petersen, Pelle, Brandt, Christian Thomas, Hillig, Thore, Friis-Hansen, Lennart Jan, Jensen, Andreas Vestergaard   +6 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source