Results 111 to 120 of about 24,572,306 (303)

Breaking the Silent Barrier: Engineering Antibodies for Brain-Targeted Rabies Immunotherapy

Pharmaceutics
Rabies remains one of the clearest therapeutic paradoxes in infectious diseases: it is largely preventable before neuroinvasion, yet once clinical symptoms appear, mortality approaches 100%.
Chen Sun, Liang Xiao, Xiao Guo, Wenxin Wang, Kaihong Zhang, Lei Wang, Zhiqiang Lin, Zhaohui Tang   +7 more
doaj   +1 more source

Interferon Gamma: Influence on Neural Stem Cell Function in Neurodegenerative and Neuroinflammatory Disease

Clinical Medicine Insights: Pathology, 2016
Interferon-gamma (IFNγ), a pleiotropic cytokine, is expressed in diverse neurodegenerative and neuroinflammatory conditions. Its protective mechanisms are well documented during viral infections in the brain, where IFNγ mediates non-cytolytic viral ...
Apurva Kulkarni, Priya Ganesan, Lauren A. O'Donnell   +2 more
doaj   +1 more source

Central Nervous

, 1973
A presentation slide reflecting an illustration of the Central Nervous systems, and labeled Life Science Flight Research Approach, Systems, Central ...

core  

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

The janus face of serotonin: Regenerative promoter and chronic liver disease aggravator

Heliyon
The progression of liver diseases, from viral hepatitis and fatty liver disease to cirrhosis and hepatocellular carcinoma (HCC), is the most representative series of pathological events in liver diseases.
Benliang Mao, Shoupei Liu, Shanfei Zhu, Fan Wu, Wei Yuan, Yong Yan, Bailin Wang   +6 more
doaj   +1 more source

Microglia lactylation in relation to central nervous system diseases [PDF]

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Mo, Nan, Hui Yang, Nan Mo, Le Tong, Wang, Ying, Juanqing Yue, Dong, Jianhong, Jianhong Dong, Mengxian Jia, Yang, Hui, Fan, Ziwei, Tong, Lily, Yue, Juanqing, Ying Wang, Jia, Mengxian, Ziwei Fan   +15 more
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Neuropathologic Diagnosis of Central Nervous System Viral Diseases

, 2011
The principal aim of this chapter is to provide an illustrated review of the neuropathologic features of common and recently emerging central nervous system (CNS) viral diseases. An overview of the histopathologic features common to most viral infections of the central nervous system will be provided. This will be followed by a description of the gross
openaire   +2 more sources

Diseases of the nervous system /

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and ...
Sontheimer, Harald,author.
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source