Results 101 to 110 of about 24,572,306 (303)
Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]
, 2012 B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin +5 more
core +1 more source
Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis
Advanced Science, EarlyView.Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu +17 more
wiley +1 more source
Эпилепсия и пароксизмальные состояния, 2016 : a viral infection of the central nervous system is a group of infectious diseases of high infectiousness and mortality in all age groups. Over the past decade, the structure of the viral lesions replaced polio and western encephalitis came slow and ...
N. F. Philippovich, N. V. Staheyko
doaj
Immunopathogenesis of virus diseases affecting the central nervous system
, 1996 A variety of viruses can cause diseases of the central nervous system by two different mechanisms. Cytolytic viruses exert direct effects on cells of the nervous system that result in death and cell loss. Noncytolytic viruses do not directly damage cells,
Stitz, Lothar, Bilzer, T.
core
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems
Frontiers in Molecular Neuroscience, 2019 The options available for genetic modification of cells of the central nervous system (CNS) have greatly increased in the last decade. The current panoply of viral and nonviral vectors provides multifunctional platforms to deliver expression cassettes to
Danila del Rio +7 more
doaj +1 more source
Neurobiology of Disease, 2019 Pathological mutations in GBA, encoding lysosomal glucocerebrosidase (GCase), cause Gaucher disease (GD). GD is a multi-system disease with great phenotypic variation between individuals. It has been classified into type 1 with primarily peripheral involvement and types 2 and 3 with varying degrees of neurological involvement.
Kasey L. Jackson +7 more
openaire +3 more sources
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Advanced Science, EarlyView.The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang +11 more
wiley +1 more source