Results 81 to 90 of about 151,906 (302)
, 2023 Central nervous system (CNS) diseases are currently a major challenge in medicine. One reason is the presence of the blood–brain barrier, which is a significant limitation for currently used medicinal substances that are characterized by a high ...
Barbara Strzalka-Mrozik +4 more
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Frontiers in Molecular Neuroscience, 2020 Diseases of the central nervous system (CNS) have historically been among the most difficult to treat using conventional pharmacological approaches.
Joseph Edward Rittiner +10 more
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Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
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The Role of Corticosteroids in Non-Bacterial and Secondary Encephalitis
LifeEncephalitis affects 1.9 to 14.3 people per 100,000 each year, and the mortality rate varies but can be up to 40%. After the identification of a particular microorganism in a patient with encephalitis, appropriate antimicrobial therapy should be ...
Giusy Di Flumeri +9 more
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PECULIARITIES OF CLINICAL MANIFESTATIONS OF CNS INFECTIONS IN CHILDREN
Acta Biomedica Scientifica, 2018 At present, the neuroinfections in children are a socially significant problem, as they can lead to disability and death.Aim. To reveal the patterns of clinical manifestations of neuroinfections in the children’s central nervous system.Materials and ...
T. S. Berezovskaya +2 more
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, 2022 Human immunodeficiency virus-1 (HIV-1)-associated neurodegenerative disorder (HAND) is frequently reported in HIV-infected individuals. The gp120 envelope viral protein has been implicated in the pathogenesis of HAND in HIV-1-infected patients; however ...
Jufang Huang +9 more
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Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier +3 more
wiley +1 more source
Long‐Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Evaluate clinical and laboratory correlates of abnormal neurologic exam findings after acute HIV infection (AHI). Methods Participants from the RV254/SEARCH 010 cohort in Bangkok underwent standardized neurologic examinations at Weeks 0 (AHI), 12, 96, and 288 following antiretroviral therapy (ART).
Kathryn B. Holroyd +118 more
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Revista da Sociedade Brasileira de Medicina Tropical, 2013 Introduction Herpes simplex virus (HSV) and varicella zoster virus (VZV) are responsible for a variety of human diseases, including central nervous system diseases.
Diogenes Rodrigues +2 more
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Immunopathogenesis of virus diseases affecting the central nervous system
, 1996 A variety of viruses can cause diseases of the central nervous system by two different mechanisms. Cytolytic viruses exert direct effects on cells of the nervous system that result in death and cell loss. Noncytolytic viruses do not directly damage cells,
Stitz, Lothar, Bilzer, T.
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